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Ccdc126 coiled-coil domain containing 126 [ Mus musculus (house mouse) ]

Gene ID: 57895, updated on 17-Aug-2024

Summary

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Official Symbol
Ccdc126provided by MGI
Official Full Name
coiled-coil domain containing 126provided by MGI
Primary source
MGI:MGI:1889376
See related
Ensembl:ENSMUSG00000050786 AllianceGenome:MGI:1889376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6330407D12Rik
Summary
Predicted to be located in extracellular region. Is expressed in several structures, including intestine; liver; metanephros; retina nuclear layer; and skeletal muscle. Orthologous to human CCDC126 (coiled-coil domain containing 126). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 4.2), bladder adult (RPKM 3.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc126 in Genome Data Viewer
Location:
6 B2.3; 6 23.86 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (49296204..49318521)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (49319269..49341587)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:49214021-49214322 Neighboring gene transformer 2 alpha Neighboring gene STARR-seq mESC enhancer starr_15823 Neighboring gene STARR-seq mESC enhancer starr_15824 Neighboring gene STARR-seq mESC enhancer starr_15825 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1321 Neighboring gene STARR-seq mESC enhancer starr_15828 Neighboring gene STARR-positive B cell enhancer ABC_E3654 Neighboring gene family with sequence similarity 221, member A Neighboring gene STARR-seq mESC enhancer starr_15829 Neighboring gene STARR-seq mESC enhancer starr_15830 Neighboring gene serine threonine kinase 31 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
  2. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC143769

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 126

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311112.1 → NP_001298041.1  coiled-coil domain-containing protein 126 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001298041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the coding region, leading to a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC095987, BX513032, BY126756, CK626366
    Consensus CDS
    CCDS80531.1
    UniProtKB/Swiss-Prot
    Q8BIS8
    Related
    ENSMUSP00000110135.2, ENSMUST00000114491.2
    Conserved Domains (1) summary
    pfam15027
    Location:4 → 79
    DUF4525; Domain of unknown function (DUF4525)

  2. NM_175098.6 → NP_780307.1  coiled-coil domain-containing protein 126 isoform 1 precursor

    See identical proteins and their annotated locations for NP_780307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK018135, BC095987, BX513032, BY126756
    Consensus CDS
    CCDS20125.1
    UniProtKB/Swiss-Prot
    Q3TXH2, Q501L9, Q8BIS8
    Related
    ENSMUSP00000058077.8, ENSMUST00000055559.8
    Conserved Domains (1) summary
    pfam15027
    Location:4 → 137
    DUF4525; Domain of unknown function (DUF4525)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    49296204..49318521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241420.4 → XP_011239722.1  coiled-coil domain-containing protein 126 isoform X1

    See identical proteins and their annotated locations for XP_011239722.1

    UniProtKB/Swiss-Prot
    Q3TXH2, Q501L9, Q8BIS8
    Conserved Domains (1) summary
    pfam15027
    Location:4 → 137
    DUF4525; Domain of unknown function (DUF4525)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BIS8.1 GenPept UniProtKB/Swiss-Prot:Q8BIS8

Gene LinkOut

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