pim2 Pim-2 proto-oncogene, serine/threonine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pim2provided by ZNC
Official Full Name: Pim-2 proto-oncogene, serine/threonine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000831-6
See related: Ensembl:ENSDARG00000059001 AllianceGenome:ZFIN:ZDB-GENE-000831-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: pim1; cb1068; fj47b05; wu:fj47b05
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in negative regulation of apoptotic process and regulation of mitotic cell cycle. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Is expressed in several structures, including hatching gland; notochord; periderm; polster; and yolk syncytial layer. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (8927870..8934065)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (8889285..8895480)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the Pim1 oncogene results in diminished visual function.
Title: Inhibition of the Pim1 oncogene results in diminished visual function.

Submit: New GeneRIF Correction

General gene information

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Markers

fc19d02.y1 (e-PCR)
- UniSTS:192918

fj47b05.x1 (e-PCR)
- UniSTS:188597

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hemopoiesis	NAS Non-traceable Author Statement more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IC Inferred by Curator more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase pim-2

Names: kinase pim-1; pim-1 oncogene; proviral integration site 2; serine/threonine-protein kinase Pim-1

NP_571614.2

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131539.2 → NP_571614.2 serine/threonine-protein kinase pim-2

Status: VALIDATED

Source sequence(s)

CR450685

UniProtKB/Swiss-Prot

B0UYD2, Q6DI52, Q7ZVJ5, Q8JFW9, Q9YHZ5

UniProtKB/TrEMBL

A0A8M1P8B4, Z4YHY2

Related

ENSDARP00000076422.4, ENSDART00000081985.5

Conserved Domains (2) summary

smart00220
Location:30 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:29 → 291

PKc_like; Protein Kinases, catalytic domain