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Sectm1b secreted and transmembrane 1B [ Mus musculus (house mouse) ]

Gene ID: 58210, updated on 13-Jan-2025

Summary

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Official Symbol
Sectm1bprovided by MGI
Official Full Name
secreted and transmembrane 1Bprovided by MGI
Primary source
MGI:MGI:1929083
See related
Ensembl:ENSMUSG00000039364 AllianceGenome:MGI:1929083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K12; Sectm1; 1810003C24Rik
Summary
Predicted to enable cytokine activity. Predicted to be involved in immune response and signal transduction. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human SECTM1 (secreted and transmembrane 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in large intestine adult (RPKM 72.9), small intestine adult (RPKM 72.4) and 4 other tissues See more
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Genomic context

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See Sectm1b in Genome Data Viewer
Location:
11 E2; 11 84.87 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120944248..120954377, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (121053423..121063585, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22152 Neighboring gene predicted gene 11775 Neighboring gene CD7 antigen Neighboring gene secreted and transmembrane 1A Neighboring gene predicted gene 11793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR. Mu X, et al. J Immunol, 2020 Sep 15. PMID 32769121, Free PMC Article
  2. Identification of CD7 as a cognate of the human K12 (SECTM1) protein. Lyman SD, et al. J Biol Chem, 2000 Feb 4. PMID 10652336
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.
    Title: Identification of a Novel Antisepsis Pathway: Sectm1a Enhances Macrophage Phagocytosis of Bacteria through Activating GITR.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
secreted and transmembrane protein 1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419037.1 → NP_001405966.1  secreted and transmembrane protein 1b precursor

    Status: VALIDATED

    Source sequence(s)
    AL662887
    UniProtKB/TrEMBL
    Q8CE38, Q9D966

  2. NM_001419038.1 → NP_001405967.1  secreted and transmembrane protein 1b precursor

    Status: VALIDATED

    Source sequence(s)
    AL662887
    UniProtKB/TrEMBL
    Q8CE38, Q9D966
    Related
    ENSMUSP00000125965.2, ENSMUST00000168459.8

  3. NM_001419039.1 → NP_001405968.1  secreted and transmembrane protein 1b precursor

    Status: VALIDATED

    Source sequence(s)
    AL662887
    UniProtKB/TrEMBL
    Q8CE38, Q9D966
    Related
    ENSMUSP00000116010.2, ENSMUST00000130786.2

  4. NM_026907.4 → NP_081183.3  secreted and transmembrane protein 1b precursor

    See identical proteins and their annotated locations for NP_081183.3

    Status: VALIDATED

    Source sequence(s)
    AL662887
    Consensus CDS
    CCDS25765.1
    UniProtKB/TrEMBL
    Q8CE38, Q9D966
    Related
    ENSMUSP00000045748.6, ENSMUST00000039309.12
    Conserved Domains (1) summary
    cl11960
    Location:39 → 116
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120944248..120954377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533854.1 → XP_006533917.1  secreted and transmembrane protein 1b isoform X1

    See identical proteins and their annotated locations for XP_006533917.1

    UniProtKB/TrEMBL
    Q8CE38, Q9D966
    Related
    ENSMUSP00000080217.3, ENSMUST00000081499.9
    Conserved Domains (1) summary
    cl11960
    Location:39 → 116
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL59.1 GenPept UniProtKB/Swiss-Prot:Q9JL59

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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