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Trem1 triggering receptor expressed on myeloid cells 1 [ Mus musculus (house mouse) ]

Gene ID: 58217, updated on 17-Dec-2024

Summary

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Official Symbol
Trem1provided by MGI
Official Full Name
triggering receptor expressed on myeloid cells 1provided by MGI
Primary source
MGI:MGI:1930005
See related
Ensembl:ENSMUSG00000042265 AllianceGenome:MGI:1930005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable receptor decoy activity; scaffold protein binding activity; and transmembrane signaling receptor activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be active in cell surface and extracellular space. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in bacterial pneumonia; bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in testis adult (RPKM 1.2), liver E18 (RPKM 1.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Trem1 in Genome Data Viewer
Location:
17 C; 17 23.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (48539763..48553955)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (48232713..48246927)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9830107B12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:48237942-48238143 Neighboring gene STARR-positive B cell enhancer ABC_E9956 Neighboring gene STARR-seq mESC enhancer starr_42745 Neighboring gene RIKEN cDNA A530064D06 gene Neighboring gene STARR-seq mESC enhancer starr_42746 Neighboring gene STARR-seq mESC enhancer starr_42747 Neighboring gene predicted gene, 52308 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene predicted gene, 52307 Neighboring gene triggering receptor expressed on myeloid cells 3 Neighboring gene triggering receptor expressed on myeloid cells-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Association of myeloid cells of triggering receptor-1 with left ventricular systolic dysfunction in BALB/c mice with sepsis. Zhou G, et al. Mediators Inflamm, 2014. PMID 24959004, Free PMC Article
  2. Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) Contributes to Bordetella pertussis Inflammatory Pathology. Gallop D, et al. Infect Immun, 2021 Sep 16. PMID 34097504, Free PMC Article
  3. Activation of TREM-1 induces endoplasmic reticulum stress through IRE-1α/XBP-1s pathway in murine macrophages. Dong L, et al. Mol Immunol, 2021 Jul. PMID 33957479
  4. Transcriptional regulation of mouse TREM-1 gene in RAW264.7 macrophage-like cells. Hosoda H, et al. Life Sci, 2011 Jul 18. PMID 21683719
  5. Blocking TREM-1 signaling prolongs survival of mice with Pseudomonas aeruginosa induced sepsis. Wang F, et al. Cell Immunol, 2012. PMID 22055202

See all (132) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.
    Title: Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.
  2. TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization.
    Title: TREM1 facilitates the development of gastric cancer through regulating neutrophil extracellular traps-mediated macrophage polarization.
  3. TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
    Title: TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease mouse models.
  4. Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guerin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1.
    Title: Systemic neutrophils are triggered by respiratory Bacillus Calmette- Guérin and mediate pulmonary mycobacterial clearance in synergy with the triggering receptor expressed on myeloid cells 1.
  5. Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/beta-catenin signaling.
    Title: Endothelial TREM-1 receptor regulates the blood-brain barrier integrity after intracerebral hemorrhage in mice via SYK/β-catenin signaling.
  6. Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
    Title: Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis.
  7. TREM1 activation of myeloid cells promotes antitumor immunity.
    Title: TREM1 activation of myeloid cells promotes antitumor immunity.
  8. The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
    Title: The microglial innate immune receptors TREM-1 and TREM-2 in the anterior cingulate cortex (ACC) drive visceral hypersensitivity and depressive-like behaviors following DSS-induced colitis.
  9. Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
    Title: Inhibition of TREM-1 ameliorates Lipopolysaccharide-induced depressive-like behaviors by alleviating neuroinflammation in the PFC via PI3K/Akt signaling pathway.
  10. Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice.
    Title: Radiation upregulates macrophage TREM-1 expression to exacerbate injury in mice.
Submit: New GeneRIF Correction See all GeneRIFs (96)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables receptor decoy activity ISO
Inferred from Sequence Orthology
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytokine production involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cytokine production involved in immune response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutrophil chemotaxis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neutrophil extravasation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neutrophil migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neutrophil-mediated killing of gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neutrophil-mediated killing of gram-negative bacterium IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
triggering receptor expressed on myeloid cells 1
Names
triggering receptor expressed in monocytes 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347399.1 → NP_001334328.1  triggering receptor expressed on myeloid cells 1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC241601
    Consensus CDS
    CCDS84319.1
    UniProtKB/TrEMBL
    Q14DT9
    Related
    ENSMUSP00000108877.4, ENSMUST00000113251.10

  2. NM_021406.5 → NP_067381.1  triggering receptor expressed on myeloid cells 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_067381.1

    Status: VALIDATED

    Source sequence(s)
    AC241601, AK089439
    Consensus CDS
    CCDS28860.1
    UniProtKB/Swiss-Prot
    Q3TAL7, Q9JKE2
    Related
    ENSMUSP00000038636.7, ENSMUST00000048782.7
    Conserved Domains (2) summary
    smart00410
    Location:32 → 133
    IG_like; Immunoglobulin like
    pfam07686
    Location:32 → 134
    V-set; Immunoglobulin V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    48539763..48553955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524729.5 → XP_006524792.1  triggering receptor expressed on myeloid cells 1 isoform X3

    Conserved Domains (1) summary
    pfam07686
    Location:32 → 134
    V-set; Immunoglobulin V-set domain

  2. XM_036160714.1 → XP_036016607.1  triggering receptor expressed on myeloid cells 1 isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:28 → 33
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:25 → 132
    Ig; Immunoglobulin domain

  3. XM_006524728.4 → XP_006524791.1  triggering receptor expressed on myeloid cells 1 isoform X2

    See identical proteins and their annotated locations for XP_006524791.1

    Conserved Domains (1) summary
    pfam07686
    Location:1 → 89
    V-set; Immunoglobulin V-set domain

  4. XM_006524726.5 → XP_006524789.1  triggering receptor expressed on myeloid cells 1 isoform X2

    See identical proteins and their annotated locations for XP_006524789.1

    Conserved Domains (1) summary
    pfam07686
    Location:1 → 89
    V-set; Immunoglobulin V-set domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKE2.1 GenPept UniProtKB/Swiss-Prot:Q9JKE2

Gene LinkOut

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