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Anapc5 anaphase-promoting complex subunit 5 [ Mus musculus (house mouse) ]

Gene ID: 59008, updated on 9-Dec-2024

Summary

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Official Symbol
Anapc5provided by MGI
Official Full Name
anaphase-promoting complex subunit 5provided by MGI
Primary source
MGI:MGI:1929722
See related
Ensembl:ENSMUSG00000029472 AllianceGenome:MGI:1929722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APC5; Anpc5; 2510006G12Rik
Summary
Predicted to enable protein phosphatase binding activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex. Is expressed in brain; cerebellum; and cerebral cortex. Orthologous to human ANAPC5 (anaphase promoting complex subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 122.1), CNS E14 (RPKM 119.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Anapc5 in Genome Data Viewer
Location:
5 F; 5 62.58 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (122925522..122960402, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (122787459..122822339, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14295 Neighboring gene predicted gene 10064 Neighboring gene purinergic receptor P2X, ligand-gated ion channel 4 Neighboring gene calcium/calmodulin-dependent protein kinase kinase 2, beta Neighboring gene STARR-positive B cell enhancer ABC_E3614 Neighboring gene STARR-seq mESC enhancer starr_14298 Neighboring gene STARR-positive B cell enhancer ABC_E10348 Neighboring gene STARR-positive B cell enhancer ABC_E1307 Neighboring gene STARR-positive B cell enhancer ABC_E2762 Neighboring gene predicted gene, 33044 Neighboring gene ring finger protein 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction. Ho AW, et al. PLoS One, 2013. PMID 23922952, Free PMC Article
  2. The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons. Sone M, et al. J Cell Sci, 2007 Aug 1. PMID 17623775
  3. APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Ferguson CJ, et al. Mol Cell, 2022 Jan 6. PMID 34942119, Free PMC Article
  4. Systematic identification of factors for provirus silencing in embryonic stem cells. Yang BX, et al. Cell, 2015 Sep 24. PMID 26365490, Free PMC Article
  5. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.
    Title: The anaphase-promoting complex protein 5 (AnapC5) associates with A20 and inhibits IL-17-mediated signal transduction.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K11-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K11-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K48-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein branched polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex ISO
Inferred from Sequence Orthology
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  
located_in spindle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
anaphase-promoting complex subunit 5
Names
cyclosome subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042491.2 → NP_001035956.1  anaphase-promoting complex subunit 5 isoform b

    See identical proteins and their annotated locations for NP_001035956.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC115728, BC046804, BP766822
    Consensus CDS
    CCDS80397.1
    UniProtKB/TrEMBL
    Q3TGH0, Q3TXL9, Q3UFC2
    Related
    ENSMUSP00000142922.2, ENSMUST00000200645.5
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

  2. NM_001289517.1 → NP_001276446.1  anaphase-promoting complex subunit 5 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splices sites, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC115728, AK151314, AK159713, BP766822
    Consensus CDS
    CCDS80396.1
    UniProtKB/TrEMBL
    A0A0G2JE03, Q3U5Y4
    Related
    ENSMUSP00000142579.2, ENSMUST00000197719.5
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

  3. NM_001289518.1 → NP_001276447.1  anaphase-promoting complex subunit 5 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC115728, AK151905, AK159713, BP766822
    Consensus CDS
    CCDS80400.1
    UniProtKB/TrEMBL
    A0A0G2JDM7, Q3U981
    Related
    ENSMUSP00000142429.2, ENSMUST00000196640.5
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

  4. NM_001289519.1 → NP_001276448.1  anaphase-promoting complex subunit 5 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site, which results in a frameshift, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC115728, AK075969, AK151905, BP766822
    Consensus CDS
    CCDS80399.1
    UniProtKB/TrEMBL
    A0A0G2JDE8
    Related
    ENSMUSP00000142341.2, ENSMUST00000199406.5
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

  5. NM_001289520.1 → NP_001276449.1  anaphase-promoting complex subunit 5 isoform f

    See identical proteins and their annotated locations for NP_001276449.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (f) is shorter than isoform a.
    Source sequence(s)
    AC115728, AK159713, BP766822
    Consensus CDS
    CCDS80398.1
    UniProtKB/TrEMBL
    Q3TGH0, Q3TWF7, Q3TXL9
    Related
    ENSMUSP00000143053.2, ENSMUST00000197074.5
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

  6. NM_021505.3 → NP_067480.2  anaphase-promoting complex subunit 5 isoform a

    See identical proteins and their annotated locations for NP_067480.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC115728, AK159916, BP766822
    Consensus CDS
    CCDS39258.1
    UniProtKB/Swiss-Prot
    Q3TGA7, Q80UJ6, Q80W43, Q8BTZ4, Q8BWW7, Q8C0F7, Q9CRX0, Q9CSL1, Q9JJB8
    UniProtKB/TrEMBL
    Q3THU3
    Related
    ENSMUSP00000083393.5, ENSMUST00000086216.9
    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    122925522..122960402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254742.1 → XP_030110602.1  anaphase-promoting complex subunit 5 isoform X1

    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5

  2. XM_006530429.4 → XP_006530492.1  anaphase-promoting complex subunit 5 isoform X2

    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5

  3. XM_030254743.2 → XP_030110603.1  anaphase-promoting complex subunit 5 isoform X4

    Conserved Domains (3) summary
    sd00016
    Location:233 → 267
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:20 → 153
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:239 → 339
    ANAPC5; Anaphase-promoting complex subunit 5

  4. XM_036165394.1 → XP_036021287.1  anaphase-promoting complex subunit 5 isoform X5

    UniProtKB/TrEMBL
    Q3TXL9
    Conserved Domains (3) summary
    sd00016
    Location:107 → 141
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:1 → 27
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:113 → 213
    ANAPC5; Anaphase-promoting complex subunit 5

  5. XM_036165393.1 → XP_036021286.1  anaphase-promoting complex subunit 5 isoform X3

    UniProtKB/TrEMBL
    Q3THU3
    Conserved Domains (3) summary
    sd00016
    Location:107 → 141
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:1 → 27
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:113 → 213
    ANAPC5; Anaphase-promoting complex subunit 5

RNA

  1. XR_387575.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BTZ4.1 GenPept UniProtKB/Swiss-Prot:Q8BTZ4

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