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Gde1 glycerophosphodiester phosphodiesterase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 60418, updated on 10-Jul-2024

Summary

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Official Symbol
Gde1provided by RGD
Official Full Name
glycerophosphodiester phosphodiesterase 1provided by RGD
Primary source
RGD:621788
See related
EnsemblRapid:ENSRNOG00000050445 AllianceGenome:RGD:621788
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mir16
Summary
Predicted to enable glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; and lysophospholipase activity. Predicted to be involved in N-acylethanolamine metabolic process; ethanolamine metabolic process; and phospholipid metabolic process. Is integral component of membrane. Orthologous to human GDE1 (glycerophosphodiester phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 1262.0), Kidney (RPKM 834.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gde1 in Genome Data Viewer
Location:
1q35
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182451182..182466569, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173016984..173032396, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188367550..188407125, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene transmembrane channel-like 7 Neighboring gene uncharacterized LOC120099917 Neighboring gene transmembrane channel-like 5 Neighboring gene centriolar coiled-coil protein 110 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene small nucleolar RNA SNORA24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors. Zheng B, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12576545, Free PMC Article
  2. Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis. Tsuboi K, et al. Biochim Biophys Acta, 2015 May. PMID 25596343
  3. MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Zheng B, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10760272, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glycerophosphodiester phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerophosphodiester phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerophosphodiester phosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycerophosphoinositol glycerophosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables glycerophosphoinositol glycerophosphodiesterase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lysophospholipase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysophospholipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acylethanolamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ethanolamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glycerophosphodiester phosphodiesterase 1
Names
glycerophosphoinositol glycerophosphodiesterase GDE1
lysophospholipase D GDE1
membrane-interacting protein of RGS16
NP_116004.2
XP_063128560.1
XP_063128562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032615.2 → NP_116004.2  glycerophosphodiester phosphodiesterase 1

    See identical proteins and their annotated locations for NP_116004.2

    Status: PROVISIONAL

    Source sequence(s)
    BC070897
    UniProtKB/Swiss-Prot
    Q6IRJ6, Q9JL55
    UniProtKB/TrEMBL
    A6I8I2, M0R5Q9
    Related
    ENSRNOP00000064735.3, ENSRNOT00000073233.4
    Conserved Domains (1) summary
    cd08573
    Location:68 → 323
    GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    182451182..182466569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272492.1 → XP_063128562.1  glycerophosphodiester phosphodiesterase 1 isoform X1

  2. XM_063272490.1 → XP_063128560.1  glycerophosphodiester phosphodiesterase 1 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JL55.2 GenPept UniProtKB/Swiss-Prot:Q9JL55

Gene LinkOut

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