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FASTKD5 FAST kinase domains 5 [ Homo sapiens (human) ]

Gene ID: 60493, updated on 3-Nov-2024

Summary

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Official Symbol
FASTKD5provided by HGNC
Official Full Name
FAST kinase domains 5provided by HGNC
Primary source
HGNC:HGNC:25790
See related
Ensembl:ENSG00000215251 MIM:614272; AllianceGenome:HGNC:25790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
dJ1187M17.5
Summary
Enables rRNA binding activity. Involved in mitochondrial RNA processing. Located in mitochondrial nucleoid and ribonucleoprotein granule. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 15.0), adrenal (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

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See FASTKD5 in Genome Data Viewer
Location:
20p13
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3146519..3159865, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3177419..3190765, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3127165..3140511, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3073228-3073728 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:3073729-3074229 Neighboring gene arginine vasopressin Neighboring gene RNA, 7SL, cytoplasmic 555, pseudogene Neighboring gene UBOX5 antisense RNA 1 Neighboring gene U-box domain containing 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12614 Neighboring gene uncharacterized LOC107985414

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The FASTK family proteins fine-tune mitochondrial RNA processing. Ohkubo A, et al. PLoS Genet, 2021 Nov. PMID 34748562, Free PMC Article
  2. NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation. Singh K, et al. Biochim Biophys Acta Mol Cell Res, 2018 Sep. PMID 29932989
  3. The FASTK family of proteins: emerging regulators of mitochondrial RNA biology. Jourdain AA, et al. Nucleic Acids Res, 2017 Nov 2. PMID 29036396, Free PMC Article
  4. Mitochondrial RNA Granules Are Centers for Posttranscriptional RNA Processing and Ribosome Biogenesis. Antonicka H, et al. Cell Rep, 2015 Feb 17. PMID 25683715
  5. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The FASTK family proteins fine-tune mitochondrial RNA processing.
    Title: The FASTK family proteins fine-tune mitochondrial RNA processing.
  2. Data show that the binding of FASTKD5 to mitochondrial RNA transcripts is regulated by NLRX1 which specifically interacts with FASTKD5.
    Title: NLRX1 resides in mitochondrial RNA granules and regulates mitochondrial RNA processing and bioenergetic adaptation.
  3. Despite the fact that proteins of the FASTK family FASTKD1-5 share the same domains, they exhibit various-sometimes opposing-functions in almost all steps of mitochondrial RNA metabolism.
    Title: The FASTK family of proteins: emerging regulators of mitochondrial RNA biology.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13149, FLJ58294

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial RNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
  
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
FAST kinase domain-containing protein 5, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021826.5 → NP_068598.1  FAST kinase domain-containing protein 5, mitochondrial

    See identical proteins and their annotated locations for NP_068598.1

    Status: VALIDATED

    Source sequence(s)
    AW182833, BC007413, BC011856
    Consensus CDS
    CCDS13048.1
    UniProtKB/Swiss-Prot
    Q7L8L6, Q96JN3, Q9H5D1, Q9H8Y3
    UniProtKB/TrEMBL
    B4DWZ8
    Related
    ENSP00000369618.3, ENST00000380266.4
    Conserved Domains (3) summary
    smart00952
    Location:699 → 758
    RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
    pfam06743
    Location:431 → 499
    FAST_1; FAST kinase-like protein, subdomain 1
    pfam08368
    Location:514 → 601
    FAST_2; FAST kinase-like protein, subdomain 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    3146519..3159865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    3177419..3190765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7L8L6.1 GenPept UniProtKB/Swiss-Prot:Q7L8L6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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