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GAS5 growth arrest specific 5 [ Homo sapiens (human) ]

Gene ID: 60674, updated on 13-Nov-2024

Summary

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Official Symbol
GAS5provided by HGNC
Official Full Name
growth arrest specific 5provided by HGNC
Primary source
HGNC:HGNC:16355
See related
Ensembl:ENSG00000234741 MIM:608280; AllianceGenome:HGNC:16355
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SNHG2; NCRNA00030
Summary
This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in ovary (RPKM 307.5), thyroid (RPKM 113.4) and 24 other tissues See more
Orthologs
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Genomic context

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See GAS5 in Genome Data Viewer
Location:
1q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173863901..173869045, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173222019..173227165, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173833039..173838183, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 160 Neighboring gene MPRA-validated peak463 silencer Neighboring gene centromere protein L Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2116 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:173793515-173794033 and GRCh37_chr1:173794034-173794551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:173795193-173795706 Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:173821280-173822182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830052-173830768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830769-173831485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1556 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173837597-173838796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2118 Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene small nucleolar RNA, C/D box 47 Neighboring gene small nucleolar RNA, H/ACA box 103 Neighboring gene small nucleolar RNA, C/D box 80 Neighboring gene small nucleolar RNA, C/D box 79 Neighboring gene small nucleolar RNA, C/D box 78 Neighboring gene small nucleolar RNA, C/D box 44 Neighboring gene small nucleolar RNA, C/D box 77 Neighboring gene small nucleolar RNA, C/D box 76 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173863193-173864392 Neighboring gene serpin family C member 1 Neighboring gene uncharacterized LOC124904457 Neighboring gene RNA, 5S ribosomal pseudogene 67

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long Non-coding RNA Growth Arrest-specific Transcript 5 (GAS5) Inhibits Liver Fibrogenesis through a Mechanism of Competing Endogenous RNA. Yu F, et al. J Biol Chem, 2015 Nov 20. PMID 26446789, Free PMC Article
  2. Overexpression of Growth-Arrest-Specific Transcript 5 Improved Cisplatin Sensitivity in Hepatocellular Carcinoma Through Sponging miR-222. Zhao P, et al. DNA Cell Biol, 2020 Apr. PMID 32213078
  3. Long non-coding RNA GAS5 regulates the growth and metastasis of human cervical cancer cells via induction of apoptosis and cell cycle arrest. Yan Z, et al. Arch Biochem Biophys, 2020 May 15. PMID 32105659
  4. Molecular and Cellular Mechanisms of Action of Tumour Suppressor GAS5 LncRNA. Pickard MR, et al. Genes (Basel), 2015 Jul 7. PMID 26198250, Free PMC Article
  5. The Long Noncoding RNA, Growth Arrest-Specific 5, Suppresses Gastric Cancer by Downregulating miR-21 Expression. Li W, et al. Pharmacology, 2020. PMID 31910411

See all (268) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Association of long noncoding RNA GAS5 gene polymorphism with progression of diabetic kidney disease.
    Title: Association of long noncoding RNA GAS5 gene polymorphism with progression of diabetic kidney disease.
  2. Serum Levels of Long Non-coding RNAs NEAT1, GAS5, and GAPLINC Altered in Rheumatoid Arthritis.
    Title: Serum Levels of Long Non-coding RNAs NEAT1, GAS5, and GAPLINC Altered in Rheumatoid Arthritis.
  3. Expression profiles of the lncRNA antisense GAS5-AS1 in colon biopsies from pediatric inflammatory bowel disease patients and its role in regulating sense transcript GAS5.
    Title: Expression profiles of the lncRNA antisense GAS5-AS1 in colon biopsies from pediatric inflammatory bowel disease patients and its role in regulating sense transcript GAS5.
  4. The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
    Title: The lncRNAs Gas5, MALAT1 and SNHG8 as diagnostic biomarkers for epithelial malignant pleural mesothelioma in Egyptian patients.
  5. Intron Editing Reveals SNORD-Dependent Maturation of the Small Nucleolar RNA Host Gene GAS5 in Human Cells.
    Title: Intron Editing Reveals SNORD-Dependent Maturation of the Small Nucleolar RNA Host Gene GAS5 in Human Cells.
  6. Exploring GAS5's impact on prostate cancer: Recent discoveries and emerging paradigms.
    Title: Exploring GAS5's impact on prostate cancer: Recent discoveries and emerging paradigms.
  7. Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder.
    Title: Reduction of GAS5 and FOXD3-AS1 long non-coding RNAs in patients with bipolar disorder.
  8. GAS5 silencing attenuates hypoxia-induced cardiomyocytes injury by targeting miR-21/PTEN.
    Title: GAS5 silencing attenuates hypoxia-induced cardiomyocytes injury by targeting miR-21/PTEN.
  9. Long Noncoding Rna GAS5 And Mir-137 And Two Of Their Genetic Polymorphisms Contribute To Acute Ischaemic Stroke Risk In An Egyptian Population.
    Title: Long Noncoding Rna GAS5 And Mir-137 And Two Of Their Genetic Polymorphisms Contribute To Acute Ischaemic Stroke Risk In An Egyptian Population.
  10. LncRNA GAS5 as an Inflammatory Regulator Acting through Pathway in Human Lupus.
    Title: LncRNA GAS5 as an Inflammatory Regulator Acting through Pathway in Human Lupus.
Submit: New GeneRIF Correction See all GeneRIFs (253)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: CENPL

Homology

Other Names

  • growth arrest specific 5 (non-protein coding)
  • growth arrest specific transcript 5
  • small nucleolar RNA host gene (non-protein coding) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002578.4 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000687189.2

  2. NR_152521.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000430245.5

  3. NR_152522.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000686995.2

  4. NR_152523.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000689238.2

  5. NR_152524.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000689958.2

  6. NR_152525.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827949.1

  7. NR_152526.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000693348.2

  8. NR_152527.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000687435.2

  9. NR_152528.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000687549.1

  10. NR_152529.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000449289.8

  11. NR_152530.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827948.1

  12. NR_152531.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  13. NR_152532.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000691213.2

  14. NR_152533.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000450589.7

  15. NR_152534.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000687022.2

  16. NR_186255.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000452197.6

  17. NR_186256.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827993.1

  18. NR_186257.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827970.1

  19. NR_186258.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  20. NR_186259.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827972.1

  21. NR_186260.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  22. NR_186261.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000691982.2

  23. NR_186262.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827958.1

  24. NR_186263.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000828016.1

  25. NR_186264.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000688952.2

  26. NR_186265.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000703059.1

  27. NR_186266.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827989.1

  28. NR_186267.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827992.1

  29. NR_186268.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000690761.2

  30. NR_186269.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000828009.1

  31. NR_186270.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827986.1

  32. NR_186271.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  33. NR_186272.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827979.1

  34. NR_186273.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  35. NR_186274.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  36. NR_186275.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000690228.2

  37. NR_186277.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000828007.1

  38. NR_186278.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000828020.1

  39. NR_186279.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  40. NR_186280.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827956.1

  41. NR_186281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000690448.2

  42. NR_186282.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000691137.2

  43. NR_186283.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000690172.2

  44. NR_186284.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000448718.7

  45. NR_186285.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000827981.1

  46. NR_186286.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170
    Related
    ENST00000687987.2

  47. NR_186287.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  48. NR_186288.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  49. NR_186289.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

  50. NR_186290.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL136170

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    173863901..173869045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    173222019..173227165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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