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RPL34 ribosomal protein L34 [ Homo sapiens (human) ]

Gene ID: 6164, updated on 26-Nov-2024

Summary

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Official Symbol
RPL34provided by HGNC
Official Full Name
ribosomal protein L34provided by HGNC
Primary source
HGNC:HGNC:10340
See related
Ensembl:ENSG00000109475 MIM:616862; AllianceGenome:HGNC:10340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L34; eL34
Summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in ovary (RPKM 324.7), bone marrow (RPKM 227.1) and 25 other tissues See more
Orthologs
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Genomic context

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See RPL34 in Genome Data Viewer
Location:
4q25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (108620576..108630484)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (111923483..111933392)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (109541732..109551640)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene exocyst complex component 7-like Neighboring gene EXOC7 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21797 Neighboring gene RPL34 divergent transcript Neighboring gene uncharacterized LOC101929621 Neighboring gene VISTA enhancer hs1050 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:109541270-109542469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:109574151-109574665 Neighboring gene RNA, U6 small nuclear 431, pseudogene Neighboring gene oligosaccharyltransferase complex non-catalytic subunit Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109634746-109635604 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:109635605-109636463 Neighboring gene ethanolamine-phosphate phospho-lyase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells. Liu H, et al. Oncol Rep, 2015 Nov. PMID 26323242, Free PMC Article
  2. Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells. Yang S, et al. Gene, 2016 Jan 15. PMID 26526135
  3. Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells. Wei F, et al. Oncotarget, 2016 Dec 20. PMID 27845896, Free PMC Article
  4. RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway. Zhu Y, et al. Cancer Sci, 2021 May. PMID 33675124, Free PMC Article
  5. Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational control. Luo S, et al. Sci Rep, 2016 Nov 24. PMID 27883047, Free PMC Article

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
    Title: RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
  2. Findings indicated that knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.
    Title: Knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.
  3. The present study combines an individual-based phenotypic profiling with a transdiagnostic approach and shows that several ribosomal genes including RPL34 is involved in stress vulnerability across nonclinical and clinical conditions.
    Title: Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.
  4. The RPL34 gene was highly expressed in OSCC, while silencing RPL34 could block cell proliferation and metastasis, but promote cell apoptosis, suggesting the RPL34 gene to be a new promising clinical target for OSCC therapy.
    Title: Influence of the RPL34 gene on the growth and metastasis of oral squamous cell carcinoma cells.
  5. RPL34 plays an important role in the proliferation of osteosarcoma cells.
    Title: Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational control.
  6. RPL34 functions as an oncogene that modulates the proliferation and metastasis of esophageal cancer cells in part through the inactivation of the PI3K/Akt signaling pathway
    Title: Silencing of Ribosomal Protein L34 (RPL34) Inhibits the Proliferation and Invasion of Esophageal Cancer Cells.
  7. this study shows that ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells
    Title: Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells.
  8. RPL34 plays a critical role in cell proliferation, cell cycle distribution and apoptosis of human malignant gastric cells.
    Title: RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells.
  9. over-expressed RPL34 may promote malignant proliferation of NSCLC cells, thus playing an important role in development and progress of NSCLC
    Title: Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells.
  10. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with RPL34 as demonstrated by proximity dependent biotinylation proteomics PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit HDA PubMed 
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein eL34
Names
60S ribosomal protein L34
leukemia-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000995.5 → NP_000986.2  large ribosomal subunit protein eL34

    See identical proteins and their annotated locations for NP_000986.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC106009, BM971961
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207, Q6FG66, Q9BUZ2
    Conserved Domains (1) summary
    pfam01199
    Location:1 → 96
    Ribosomal_L34e; Ribosomal protein L34e

  2. NM_001319232.2 → NP_001306161.1  large ribosomal subunit protein eL34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AA128015, AA128058, AC084209, CD175155, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207, Q6FG66, Q9BUZ2
    Related
    ENSP00000423316.1, ENST00000506397.5
    Conserved Domains (1) summary
    pfam01199
    Location:1 → 96
    Ribosomal_L34e; Ribosomal protein L34e

  3. NM_001319234.1 → NP_001306163.1  large ribosomal subunit protein eL34

    Status: REVIEWED

    Source sequence(s)
    CB132938, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207, Q6FG66, Q9BUZ2
    Conserved Domains (1) summary
    pfam01199
    Location:1 → 96
    Ribosomal_L34e; Ribosomal protein L34e

  4. NM_001319235.2 → NP_001306164.1  large ribosomal subunit protein eL34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AC084209, BE394007, CD175155, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207, Q6FG66, Q9BUZ2
    Related
    ENSP00000378160.1, ENST00000394665.5
    Conserved Domains (1) summary
    pfam01199
    Location:1 → 96
    Ribosomal_L34e; Ribosomal protein L34e

  5. NM_001319236.2 → NP_001306165.1  large ribosomal subunit protein eL34

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.
    Source sequence(s)
    BC106009, DA779124
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207, Q6FG66, Q9BUZ2
    Related
    ENSP00000378162.3, ENST00000394667.8
    Conserved Domains (1) summary
    pfam01199
    Location:1 → 96
    Ribosomal_L34e; Ribosomal protein L34e

  6. NM_033625.4 → NP_296374.1  large ribosomal subunit protein eL34

    See identical proteins and their annotated locations for NP_296374.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AC084209, BC001773, BM971961, CD175155
    Consensus CDS
    CCDS3680.1
    UniProtKB/Swiss-Prot
    P49207, Q6FG66, Q9BUZ2
    Related
    ENSP00000378163.2, ENST00000394668.3
    Conserved Domains (1) summary
    pfam01199
    Location:1 → 96
    Ribosomal_L34e; Ribosomal protein L34e

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    108620576..108630484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    111923483..111933392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49207.3 GenPept UniProtKB/Swiss-Prot:P49207

Gene LinkOut

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