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ston2 stonin 2 [ Danio rerio (zebrafish) ]

Gene ID: 619262, updated on 2-Nov-2024

Summary

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Official Symbol
ston2provided by ZNC
Official Full Name
stonin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-050913-137
See related
Ensembl:ENSDARG00000057452 AllianceGenome:ZFIN:ZDB-GENE-050913-137
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc70h07; wu:fc70h07; zgc:113338
Summary
Predicted to enable clathrin adaptor activity. Predicted to be involved in clathrin-dependent endocytosis; regulation of endocytosis; and synaptic vesicle endocytosis. Predicted to act upstream of or within endocytosis. Predicted to be located in cytoplasm. Predicted to be part of AP-2 adaptor complex. Predicted to be active in synaptic vesicle. Orthologous to human STON2 (stonin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ston2 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (16755287..16804960)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (16747354..16797189)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488083 Neighboring gene forkhead box N3 Neighboring gene iodothyronine deiodinase 2 Neighboring gene neurexin 3a Neighboring gene uncharacterized LOC137488084

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Multiple thyrotropin β-subunit and thyrotropin receptor-related genes arose during vertebrate evolution. Maugars G, et al. PLoS One, 2014. PMID 25386660, Free PMC Article
  2. Transcriptome analysis reveals positive selection on the divergent between topmouth culter and zebrafish. Ren L, et al. Gene, 2014 Dec 1. PMID 25267534
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC113338

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stonin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033743.1 → NP_001028915.1  stonin-2

    See identical proteins and their annotated locations for NP_001028915.1

    Status: PROVISIONAL

    Source sequence(s)
    BC096906
    UniProtKB/TrEMBL
    Q4V9G6
    Related
    ENSDARP00000074579.2, ENSDART00000080129.4
    Conserved Domains (2) summary
    pfam12016
    Location:62 → 287
    Stonin2_N; Stonin 2
    cl10970
    Location:522 → 839
    AP_MHD_Cterm; C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    16755287..16804960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169836.5 → XP_005169893.1  stonin-2 isoform X1

    See identical proteins and their annotated locations for XP_005169893.1

    UniProtKB/TrEMBL
    A0A8M2BH18
    Conserved Domains (2) summary
    cd09263
    Location:370 → 687
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1 → 135
    Stonin2_N; Stonin 2

  2. XM_005169837.5 → XP_005169894.1  stonin-2 isoform X1

    See identical proteins and their annotated locations for XP_005169894.1

    UniProtKB/TrEMBL
    A0A8M2BH18
    Conserved Domains (2) summary
    cd09263
    Location:370 → 687
    AP_stonin-2_MHD; Mu homology domain (MHD) of adaptor-like protein (AP-like), stonin-2
    pfam12016
    Location:1 → 135
    Stonin2_N; Stonin 2
Nucleotide Protein Strain
Heading Accession and Version

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