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Ncoa4 nuclear receptor coactivator 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619385, updated on 2-Nov-2024

Summary

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Official Symbol
Ncoa4provided by RGD
Official Full Name
nuclear receptor coactivator 4provided by RGD
Primary source
RGD:1563014
See related
EnsemblRapid:ENSRNOG00000019768 AllianceGenome:RGD:1563014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coactivator activity. Involved in response to hormone. Predicted to be located in autolysosome. Orthologous to human NCOA4 (nuclear receptor coactivator 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 1656.7), Kidney (RPKM 587.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ncoa4 in Genome Data Viewer
Location:
16p16
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7395502..7415846)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7389222..7409564)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8302950..8323294)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene oxidoreductase NAD-binding domain containing 1 Neighboring gene transfer RNA valine (anticodon AAC) 12 Neighboring gene uncharacterized LOC134482455 Neighboring gene microseminoprotein, beta Neighboring gene poly (ADP-ribose) glycohydrolase like 1 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene uncharacterized LOC134482454

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Direct regulation of androgen receptor-associated protein 70 by thyroid hormone and its receptors. Tai PJ, et al. Endocrinology, 2007 Jul. PMID 17412801
  2. Evaluation of steroid receptors, coregulators, and molecules associated with uterine receptivity in secretory endometria from untreated women with polycystic ovary syndrome. Quezada S, et al. Fertil Steril, 2006 Apr. PMID 16580389
  3. Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. Hu YC, et al. J Biol Chem, 2004 Aug 6. PMID 15166229
  4. Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Li P, et al. Am J Pathol, 2002 Oct. PMID 12368219, Free PMC Article
  5. Loss of androgen receptor associated protein 70 (ARA70) expression in a subset of HER2-positive breast cancers. Kollara A, et al. Breast Cancer Res Treat, 2001 Jun. PMID 11561770

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
    Title: m6A reader YTHDC2 mediates NCOA4 mRNA stability affecting ferritinophagy to alleviate secondary injury after intracerebral haemorrhage.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC72479

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein targeting to lysosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in autolysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor coactivator 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034007.1 → NP_001029179.1  nuclear receptor coactivator 4

    See identical proteins and their annotated locations for NP_001029179.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI031008, AI112421, BC061839, CB806310, CV119475, CV795771
    UniProtKB/TrEMBL
    A0A8I6A3B1, A6KFW8, B1H215, F7FLG1
    Related
    ENSRNOP00000026803.4, ENSRNOT00000026803.7
    Conserved Domains (1) summary
    pfam12489
    Location:231 → 323
    ARA70; Nuclear coactivator

  2. NM_001034008.1 → NP_001029180.1  nuclear receptor coactivator 4

    See identical proteins and their annotated locations for NP_001029180.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AI031008, AI112421, BC061839, CB758330, CV119475, CV795771
    UniProtKB/TrEMBL
    A0A8I6A3B1, A6KFW8, B1H215, F7FLG1
    Conserved Domains (1) summary
    pfam12489
    Location:231 → 323
    ARA70; Nuclear coactivator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    7395502..7415846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006252660.5 → XP_006252722.1  nuclear receptor coactivator 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A1Q3, A0A8I6A3B1
    Related
    ENSRNOP00000061299.2, ENSRNOT00000066062.5
    Conserved Domains (1) summary
    pfam12489
    Location:239 → 331
    ARA70; Nuclear coactivator
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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