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Majin membrane anchored junction protein [ Mus musculus (house mouse) ]

Gene ID: 622554, updated on 17-Aug-2024

Summary

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Official Symbol
Majinprovided by MGI
Official Full Name
membrane anchored junction proteinprovided by MGI
Primary source
MGI:MGI:1923913
See related
Ensembl:ENSMUSG00000024786 AllianceGenome:MGI:1923913
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700123I01Rik
Summary
Predicted to enable DNA binding activity. Involved in homologous chromosome pairing at meiosis and meiotic attachment of telomere to nuclear envelope. Located in chromosome, telomeric region. Is integral component of nuclear inner membrane. Orthologous to human MAJIN (membrane anchored junction protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.9) and large intestine adult (RPKM 0.2) See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6234358..6274349)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6184345..6224230)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted pseudogene 5510 Neighboring gene basic leucine zipper transcription factor, ATF-like 2 Neighboring gene protein phosphatase 2, regulatory subunit B', beta Neighboring gene STARR-positive B cell enhancer ABC_E9990 Neighboring gene STARR-positive B cell enhancer ABC_E5681 Neighboring gene glycoprotein hormone alpha 2 Neighboring gene STARR-positive B cell enhancer ABC_E619 Neighboring gene autophagy related 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans. da Cruz I, et al. BMC Evol Biol, 2020 May 14. PMID 32408858, Free PMC Article
  2. Distinct TERB1 Domains Regulate Different Protein Interactions in Meiotic Telomere Movement. Zhang J, et al. Cell Rep, 2017 Nov 14. PMID 29141207
  3. CRISPR/Cas9-based genetic screen of SCNT-reprogramming resistant genes identifies critical genes for male germ cell development in mice. Akter MS, et al. Sci Rep, 2021 Jul 29. PMID 34326397, Free PMC Article
  4. Speedy A-Cdk2 binding mediates initial telomere-nuclear envelope attachment during meiotic prophase I independent of Cdk2 activation. Tu Z, et al. Proc Natl Acad Sci U S A, 2017 Jan 17. PMID 28031483, Free PMC Article
  5. MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap. Shibuya H, et al. Cell, 2015 Nov 19. PMID 26548954

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.
    Title: The TERB1-TERB2-MAJIN complex of mouse meiotic telomeres dates back to the common ancestor of metazoans.
  2. The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope
    Title: The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
  3. Study identified meiosis-specific telomere and inner nuclear membrane-binding proteins, telomere repeat-binding bouquet formation protein 2 (TERB2) and membrane-anchored junction protein (MAJIN), which form a complex with TERB1.
    Title: MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within double-strand break repair involved in meiotic recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homologous chromosome pairing at meiosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic attachment of telomere to nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within meiotic attachment of telomere to nuclear envelope IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic attachment of telomere to nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within meiotic cell cycle process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane-anchored junction protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165919.2 → NP_001159391.1  membrane-anchored junction protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC127556
    Consensus CDS
    CCDS50364.1
    UniProtKB/Swiss-Prot
    E9Q4N4, Q9D992
    UniProtKB/TrEMBL
    B2RQN5
    Related
    ENSMUSP00000109156.2, ENSMUST00000113528.2
    Conserved Domains (1) summary
    pfam15077
    Location:1 → 240
    MAJIN; Membrane-anchored junction protein

  2. NM_001377074.1 → NP_001364003.1  membrane-anchored junction protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127556
    Conserved Domains (1) summary
    pfam15077
    Location:1 → 182
    MAJIN; Membrane-anchored junction protein

  3. NM_001377075.1 → NP_001364004.1  membrane-anchored junction protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127556
    Related
    ENSMUSP00000025699.3, ENSMUST00000025699.9
    Conserved Domains (1) summary
    pfam15077
    Location:1 → 108
    MAJIN; Membrane-anchored junction protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6234358..6274349
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161650.1 → XP_036017543.1  membrane-anchored junction protein isoform X2

    Conserved Domains (1) summary
    pfam15077
    Location:1 → 129
    MAJIN; Membrane-anchored junction protein

  2. XM_011248644.3 → XP_011246946.1  membrane-anchored junction protein isoform X1

    UniProtKB/TrEMBL
    B2RQN5
    Conserved Domains (1) summary
    pfam15077
    Location:14 → 221
    MAJIN; Membrane-anchored junction protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D992.2 GenPept UniProtKB/Swiss-Prot:Q9D992

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