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Cntnap5a contactin associated protein-like 5A [ Mus musculus (house mouse) ]

Gene ID: 636808, updated on 9-Dec-2024

Summary

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Official Symbol
Cntnap5aprovided by MGI
Official Full Name
contactin associated protein-like 5Aprovided by MGI
Primary source
MGI:MGI:3643623
See related
Ensembl:ENSMUSG00000070695 AllianceGenome:MGI:3643623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Caspr5-1; EG636808
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell adhesion and proteolysis. Predicted to be located in membrane and neuron projection. Is expressed in central nervous system. Orthologous to human CNTNAP5 (contactin associated protein family member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in CNS E18 (RPKM 2.7), cortex adult (RPKM 2.4) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Cntnap5a in Genome Data Viewer
Location:
1 E2.3; 1 51.59 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (115612467..116515053)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (115684737..116587323)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01947 Neighboring gene leukotriene A4 hydrolase pseudogene Neighboring gene STARR-seq mESC enhancer starr_01948 Neighboring gene STARR-seq mESC enhancer starr_01949 Neighboring gene STARR-seq mESC enhancer starr_01950 Neighboring gene predicted gene, 50605 Neighboring gene tubulin, beta 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_01951 Neighboring gene STARR-seq mESC enhancer starr_01952 Neighboring gene STARR-seq mESC enhancer starr_01953 Neighboring gene STARR-seq mESC enhancer starr_01955 Neighboring gene STARR-seq mESC enhancer starr_01956 Neighboring gene STARR-seq mESC enhancer starr_01957 Neighboring gene STARR-seq mESC enhancer starr_01959 Neighboring gene STARR-seq mESC enhancer starr_01960 Neighboring gene STARR-seq mESC enhancer starr_01962 Neighboring gene STARR-seq mESC enhancer starr_01963 Neighboring gene predicted gene, 17777 Neighboring gene predicted gene, 24030

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Weichenhan D, et al. Mamm Genome, 2008 Oct-Dec. PMID 18949514
  2. New members of the neurexin superfamily: multiple rodent homologues of the human CASPR5 gene. Traut W, et al. Mamm Genome, 2006 Jul. PMID 16845472
  3. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
contactin-associated protein like 5-1
Names
cell recognition molecule Caspr5-1
cell recognition molecule Caspr5a
contactin-associated protein-like 5a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077425.2 → NP_001070893.1  contactin-associated protein like 5-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001070893.1

    Status: VALIDATED

    Source sequence(s)
    AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403
    Consensus CDS
    CCDS35689.1
    UniProtKB/Swiss-Prot
    Q0V8T9
    Related
    ENSMUSP00000035732.9, ENSMUST00000043725.9
    Conserved Domains (6) summary
    smart00282
    Location:205 → 338
    LamG; Laminin G domain
    cd00054
    Location:960 → 994
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:56 → 173
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:792 → 936
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:550 → 581
    EGF; EGF-like domain
    pfam02210
    Location:395 → 518
    Laminin_G_2; Laminin G domain

  2. NM_001371013.1 → NP_001357942.1  contactin-associated protein like 5-1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC098737, AC110160, AC122189, AC122812, AC124547, AC124690, AC132403
    Conserved Domains (6) summary
    smart00282
    Location:205 → 338
    LamG; Laminin G domain
    cd00054
    Location:961 → 995
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:56 → 173
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:793 → 937
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:551 → 582
    EGF; EGF-like domain
    pfam02210
    Location:396 → 519
    Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    115612467..116515053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529774.4 → XP_006529837.1  contactin-associated protein like 5-1 isoform X1

    Conserved Domains (6) summary
    smart00282
    Location:144 → 277
    LamG; Laminin G domain
    cd00054
    Location:900 → 934
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00057
    Location:2 → 112
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cd00110
    Location:732 → 876
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00008
    Location:490 → 521
    EGF; EGF-like domain
    pfam02210
    Location:335 → 458
    Laminin_G_2; Laminin G domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0V8T9.1 GenPept UniProtKB/Swiss-Prot:Q0V8T9

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