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Iqcn IQ motif containing N [ Mus musculus (house mouse) ]

Gene ID: 637079, updated on 4-Jan-2025

Summary

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Official Symbol
Iqcnprovided by MGI
Official Full Name
IQ motif containing Nprovided by MGI
Primary source
MGI:MGI:3708784
See related
Ensembl:ENSMUSG00000110622 AllianceGenome:MGI:3708784
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm16486
Summary
Involved in spermatid development. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 78. Orthologous to human IQCN (IQ motif containing N). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Restricted expression toward testis adult (RPKM 68.7) See more
Orthologs
human all
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Genomic context

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See Iqcn in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71154661..71170299)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70701321..70717650)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39191 Neighboring gene STARR-positive B cell enhancer ABC_E6647 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73219441-73219628 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73222195-73222304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:73222558-73222745 Neighboring gene STARR-positive B cell enhancer ABC_E6648 Neighboring gene jun D proto-oncogene Neighboring gene predicted gene, 34255 Neighboring gene predicted gene 3336 Neighboring gene phosphodiesterase 4C, cAMP specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure. Wang Y, et al. Mol Hum Reprod, 2023 Jun 30. PMID 37184908
  2. IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect. Dai J, et al. EMBO Mol Med, 2022 Dec 7. PMID 36321563, Free PMC Article
  3. Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility. Li Q, et al. Hum Reprod, 2023 Jul 5. PMID 37140151
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
    Title: Biallelic variants in IQCN cause sperm flagellar assembly defects and male infertility.
  2. Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.
    Title: Loss-of-function mutations in IQCN cause male infertility in humans and mice owing to total fertilization failure.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in spermatid development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatid development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
IQ domain-containing protein N

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370846.1 → NP_001357775.1  IQ domain-containing protein N

    Status: VALIDATED

    Source sequence(s)
    AC162446
    UniProtKB/Swiss-Prot
    A0A1D5RMD1
    UniProtKB/TrEMBL
    A0A9L6JPS2
    Related
    ENSMUSP00000148728.2, ENSMUST00000212436.2
    Conserved Domains (2) summary
    smart00015
    Location:1360 → 1381
    IQ; Calmodulin-binding motif
    PRK14971
    Location:280 → 384
    PRK14971; DNA polymerase III subunit gamma/tau

  2. NM_001370847.1 → NP_001357776.1  IQ domain-containing protein N

    Status: VALIDATED

    Source sequence(s)
    AC162446
    UniProtKB/Swiss-Prot
    A0A1D5RMD1
    UniProtKB/TrEMBL
    A0A9L6JPS2
    Conserved Domains (2) summary
    smart00015
    Location:1360 → 1381
    IQ; Calmodulin-binding motif
    PRK14971
    Location:280 → 384
    PRK14971; DNA polymerase III subunit gamma/tau

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71154661..71170299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154224.1 → XP_036010117.1  IQ domain-containing protein N isoform X1

    Conserved Domains (3) summary
    smart00015
    Location:3061 → 3082
    IQ; Calmodulin-binding motif
    PHA03247
    Location:1714 → 2275
    PHA03247; large tegument protein UL36; Provisional
    PRK14971
    Location:280 → 384
    PRK14971; DNA polymerase III subunit gamma/tau
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1D5RMD1.2 GenPept UniProtKB/Swiss-Prot:A0A1D5RMD1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials