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SEC14L1 SEC14 like lipid binding 1 [ Homo sapiens (human) ]

Gene ID: 6397, updated on 2-Nov-2024

Summary

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Official Symbol
SEC14L1provided by HGNC
Official Full Name
SEC14 like lipid binding 1provided by HGNC
Primary source
HGNC:HGNC:10698
See related
Ensembl:ENSG00000129657 MIM:601504; AllianceGenome:HGNC:10698
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC14L; PRELID4A
Summary
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]
Expression
Ubiquitous expression in placenta (RPKM 29.8), testis (RPKM 26.1) and 25 other tissues See more
Orthologs
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Genomic context

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See SEC14L1 in Genome Data Viewer
Location:
17q25.2-q25.3
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (77088685..77217101)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (77981537..78110663)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (75084767..75213183)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74881066-74881940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74901567-74902178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74902179-74902790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74912167-74912666 Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74933764-74934306 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74936614-74937172 Neighboring gene uncharacterized LOC105371899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:74953917-74954830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9030 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74965460-74966084 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74979338-74979875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74978799-74979337 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74991281-74991822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:74993993-74994533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75048917-75049660 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75052409-75052622 Neighboring gene Sharpr-MPRA regulatory region 11385 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:75084131-75085330 Neighboring gene NANOG hESC enhancer GRCh37_chr17:75102846-75103510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12822 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12823 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75120061-75120834 Neighboring gene uncharacterized LOC105371901 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12824 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75129013-75129514 Neighboring gene microRNA 6516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9031 Neighboring gene small nucleolar RNA host gene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9033 Neighboring gene Sharpr-MPRA regulatory region 40 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75159437-75159938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75181881-75182382 Neighboring gene RNA, U4 small nuclear 47, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75182383-75182882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75213877-75214400 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:75217127-75217628 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:75217629-75218128 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:75229305-75230504 Neighboring gene Sharpr-MPRA regulatory region 14112 Neighboring gene CYCS pseudogene 40 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:75243257-75244107 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:75250208-75251407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75253655-75254312 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75254313-75254968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75262063-75262564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75262565-75263064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:75275663-75276310 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:75277912-75278075 Neighboring gene SEPTIN9 divergent transcript Neighboring gene lung adenocarcinoma-associated transcript 1 Neighboring gene septin 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Evaluation of Saccharomyces cerevisiae -like 1 (SEC14L1) in Gynecologic Malignancies Shows Overexpression in Endometrial Serous Carcinoma. Banet N, et al. Int J Gynecol Pathol, 2023 Mar 1. PMID 35283446
  2. Isolation and mapping of a human gene (SEC14L), partially homologous to yeast SEC14, that contains a variable number of tandem repeats (VNTR) site in its 3' untranslated region. Chinen K, et al. Cytogenet Cell Genet, 1996. PMID 8697811
  3. Genomic characterization of human SEC14L1 splice variants within a 17q25 candidate tumor suppressor gene region and identification of an unrelated embedded expressed sequence tag. Kalikin LM, et al. Mamm Genome, 2001 Dec. PMID 11707779
  4. Saccharomyces cerevisiae-like 1 (SEC14L1) is a prognostic factor in breast cancer associated with lymphovascular invasion. Sonbul SN, et al. Mod Pathol, 2018 Nov. PMID 29955149
  5. Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers. Burdelski C, et al. Hum Pathol, 2015 Apr. PMID 25701228

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Evaluation of Saccharomyces cerevisiae -like 1 (SEC14L1) in Gynecologic Malignancies Shows Overexpression in Endometrial Serous Carcinoma.
    Title: Evaluation of Saccharomyces cerevisiae -like 1 (SEC14L1) in Gynecologic Malignancies Shows Overexpression in Endometrial Serous Carcinoma.
  2. Our findings specify SEC14L1 as an independent prognostic factor in breast cancer.
    Title: Saccharomyces cerevisiae-like 1 (SEC14L1) is a prognostic factor in breast cancer associated with lymphovascular invasion.
  3. we present genetic evidence that NGx04 inhibits fungal Sec14p and initial data supporting NGx04 as a novel antifungal starting point.
    Title: High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines.
  4. a markedly different role of SEC14L1 in TMPSSR2:ERG-negative and TMPSSR2:ERG-positive prostate cancers
    Title: Saccharomyces cerevisiae-like 1 overexpression is frequent in prostate cancer and has markedly different effects in Ets-related gene fusion-positive and fusion-negative cancers.
  5. Sec14 and Sec14 like proteins form central conduits to integrate multiple aspects of lipid metabolism with productive phosphoinositide signaling. (Review)
    Title: Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality.
  6. These findings suggest that SEC14L1 functions as a novel negative regulator of RIG-I-mediated antiviral signaling by preventing RIG-I interaction with the downstream effector.
    Title: Negative regulation of RIG-I-mediated innate antiviral signaling by SEC14L1.
  7. TCEB1 and SELC14L1 are good candidate markers for predicting prognosis and progression of prostate cancer.
    Title: A 12-gene expression signature is associated with aggressive histological in prostate cancer: SEC14L1 and TCEB1 genes are potential markers of progression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
EBI GWAS Catalog
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
EBI GWAS Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of SEC14-like 1 (SEC14L1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686C06176

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RIG-I binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RIG-I binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein sequestering activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in choline transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of RIG-I signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of RIG-I signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IC
Inferred by Curator
more info
 PubMed 
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
SEC14-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050640.2 RefSeqGene

    Range
    57327..133459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039573.3 → NP_001034662.3  SEC14-like protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is alternatively spliced in the 3' coding region, compared to variant 3. Variants 2 and 6 encode isoform b, which is longer than isoform a.
    Source sequence(s)
    AC068594
    UniProtKB/TrEMBL
    A5PLM6
    Related
    ENSP00000406030.3, ENST00000443798.8
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  2. NM_001143998.2 → NP_001137470.2  SEC14-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is the longest transcript but encodes the shortest isoform (a).
    Source sequence(s)
    AC068594
    UniProtKB/Swiss-Prot
    A8K4E8, B4DDI5, D5G3K1, Q92503, Q99780
    UniProtKB/TrEMBL
    Q7Z3R7
    Related
    ENSP00000390392.3, ENST00000436233.9
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  3. NM_001143999.2 → NP_001137471.2  SEC14-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 1, 3, 4 and 7 encode isoform a.
    Source sequence(s)
    AC068594
    UniProtKB/Swiss-Prot
    A8K4E8, B4DDI5, D5G3K1, Q92503, Q99780
    UniProtKB/TrEMBL
    Q7Z3R7
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  4. NM_001144001.2 → NP_001137473.2  SEC14-like protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three 5' exons, has an alternate 5' UTR exon, and initiates translation at a downstream start codon, compared to variant 3. It encodes isoform c which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC068594
    Consensus CDS
    CCDS45789.1
    UniProtKB/TrEMBL
    Q7Z3R7
    Related
    ENSP00000389838.1, ENST00000431431.6
    Conserved Domains (3) summary
    smart01100
    Location:222 → 267
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:292 → 456
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:1 → 139
    PRELI; PRELI-like family

  5. NM_001204408.2 → NP_001191337.2  SEC14-like protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and is alternatively spliced in the 3' coding region, compared to variant 1. It encodes isoform b, which is longer than isoform a. This variant is a read-through transcript between the upstream non-coding C17orf86 locus (GeneID:654434) and the downstream SEC14L1 locus (GeneID:6397).
    Source sequence(s)
    AC015815, AC068594
    UniProtKB/TrEMBL
    A5PLM6
    Related
    ENSP00000376268.2, ENST00000392476.6
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  6. NM_001204410.2 → NP_001191339.2  SEC14-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 3, 4 and 7 encode isoform a. This variant is a read-through transcript between the upstream non-coding C17orf86 locus (GeneID:654434) and the downstream SEC14L1 locus (GeneID:6397).
    Source sequence(s)
    AC015815, AC068594, FM995496
    UniProtKB/Swiss-Prot
    A8K4E8, B4DDI5, D5G3K1, Q92503, Q99780
    UniProtKB/TrEMBL
    Q7Z3R7
    Related
    ENSP00000408169.3, ENST00000430767.8
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

  7. NM_003003.4 → NP_002994.4  SEC14-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 3. Variants 1, 3, 4 and 7 encode isoform a.
    Source sequence(s)
    AC068594
    UniProtKB/Swiss-Prot
    A8K4E8, B4DDI5, D5G3K1, Q92503, Q99780
    UniProtKB/TrEMBL
    Q7Z3R7
    Related
    ENSP00000466581.1, ENST00000585618.5
    Conserved Domains (3) summary
    smart01100
    Location:256 → 301
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam00650
    Location:326 → 490
    CRAL_TRIO; CRAL/TRIO domain
    pfam04707
    Location:17 → 173
    PRELI; PRELI-like family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    77088685..77217101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    77981537..78110663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92503.2 GenPept UniProtKB/Swiss-Prot:Q92503

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