Nrgn neurogranin [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrgnprovided by MGI
Official Full Name: neurograninprovided by MGI
Primary source: MGI:MGI:1927184
See related: Ensembl:ENSMUSG00000053310 AllianceGenome:MGI:1927184
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NG; RC3; Pss1; NG/RC3; 0710001B06Rik
Summary: Enables calmodulin binding activity. Predicted to be involved in positive regulation of long-term synaptic potentiation and postsynaptic modulation of chemical synaptic transmission. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in several cellular components, including dendritic spine head; neuronal cell body; and trans-Golgi network transport vesicle membrane. Predicted to be active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and stomach. Orthologous to human NRGN (neurogranin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 666.1), frontal lobe adult (RPKM 395.9) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 20.78 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (37455789..37464041, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (37544493..37552745, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion.
Title: Neurogranin as an important regulator in swimming training to improve the spatial memory dysfunction of mice with chronic cerebral hypoperfusion.
The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.
Title: The effects of neurogranin knockdown on SERCA pump efficiency in soleus muscles of female mice fed a high fat diet.
Neurogranin inhibits calcineurin in murine soleus muscle: Effects of heterozygous knockdown on muscle adaptations to tenotomy and fatigue resistance.
Title: Neurogranin inhibits calcineurin in murine soleus muscle: Effects of heterozygous knockdown on muscle adaptations to tenotomy and fatigue resistance.
Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice.
Title: Decreased nesting behavior, selective increases in locomotor activity in a novel environment, and paradoxically increased open arm exploration in Neurogranin knockout mice.
Neurogranin is expressed in skeletal muscle where it is a novel regulator of calcineurin signaling.
Title: Neurogranin is expressed in mammalian skeletal muscle and inhibits calcineurin signaling and myoblast fusion.
lack of Ng in mice decreases prepulse inhibition (PPI). Ng over-expression in the prefrontal cortex (PFC) increases PPI, while Ng expression in either the nucleus accumbens (NAc) or hippocampus induces no change in PPI.
Title: Neurogranin regulates sensorimotor gating through cortico-striatal circuitry.
Myeloid SIRT1 knockout (KO) mice exhibited higher food intake, weight gain, and lower expression of anorexigenic proopiomelanocortin in the arcuate nucleus than WT mice. In particular, KO mice had lower ventromedial hypothalamus (VMH)-specific neurogranin expression.
Title: Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet.
The findings of this study specifically suggest that accumbal Ng plays an essential role in the counterbalance between NMDAR and mGluR5 signaling.
Title: Neurogranin in the nucleus accumbens regulates NMDA receptor tolerance and motivation for ethanol seeking.
The results of this study indicated that elevated neurogranin function within the PFC can enhance local plasticity and increase the rate of extinction learning across different behavioral tasks.
Title: Increased prefrontal cortex neurogranin enhances plasticity and extinction learning.
Neurogranin knockout mice are hyperactive and socially withdrawn.
Title: Methylphenidate improves the behavioral and cognitive deficits of neurogranin knockout mice.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU040484 (e-PCR)
- UniSTS:159861

UniSTS:224475 (e-PCR)
- UniSTS:224475

RH125210 (e-PCR)
- UniSTS:162032

AI838505 (e-PCR)
- UniSTS:165621

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in dendritic spine head	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: neurogranin

Names: neurogranin (protein kinase C substrate, RC3); postsynaptic spine 1; protein kinase C substrate

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.