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Parvg parvin, gamma [ Mus musculus (house mouse) ]

Gene ID: 64099, updated on 2-Nov-2024

Summary

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Official Symbol
Parvgprovided by MGI
Official Full Name
parvin, gammaprovided by MGI
Primary source
MGI:MGI:2158329
See related
Ensembl:ENSMUSG00000022439 AllianceGenome:MGI:2158329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including cell projection assembly; establishment or maintenance of cell polarity regulating cell shape; and substrate adhesion-dependent cell spreading. Predicted to be located in cytoskeleton and plasma membrane. Predicted to be active in actin cytoskeleton; cytoplasm; and focal adhesion. Is expressed in alimentary system; embryo mesenchyme; hemolymphoid system; liver; and thymus primordium. Orthologous to human PARVG (parvin gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 40.8), spleen adult (RPKM 24.7) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Parvg in Genome Data Viewer
Location:
15 E2; 15 39.78 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (84208388..84227179)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (84324175..84342978)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33723 Neighboring gene parvin, beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84146147-84146300 Neighboring gene predicted gene, 22890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84185775-84185884 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunitNalpha acetyltransferase 10 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:84214597-84214798 Neighboring gene shisa like 1 Neighboring gene predicted gene, 46527

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response. Chu H, et al. Mol Cell Biol, 2006 Mar. PMID 16479001, Free PMC Article
  2. The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Thievessen I, et al. Curr Biol, 2022 Jul 25. PMID 35688156
  3. Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans. Korenbaum E, et al. Gene, 2001 Nov 14. PMID 11722847
  4. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily. Olski TM, et al. J Cell Sci, 2001 Feb. PMID 11171322
  5. Src homology 2 (SH2)-containing 5'-inositol phosphatase localizes to podosomes, and the SH2 domain is implicated in the attenuation of bone resorption in osteoclasts. Yogo K, et al. Endocrinology, 2006 Jul. PMID 16601135

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mammalian parvins are likely to have arisen late in evolution from gene duplication as they share a remarkably similar exon/intron organization.
    Title: Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans.
  2. despite the high expression of gamma-parvin in hematopoietic cells it must play a more subtle role for blood cell homeostasis
    Title: gamma-Parvin is dispensable for hematopoiesis, leukocyte trafficking, and T-cell-dependent antibody response.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in establishment or maintenance of cell polarity regulating cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
gamma-parvin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162500.1 → NP_001155972.1  gamma-parvin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK079881, AL626769, BY200543
    Consensus CDS
    CCDS49686.1
    UniProtKB/TrEMBL
    E9PYG5, Q8C2K9, Q8CEF2
    Related
    ENSMUSP00000131443.2, ENSMUST00000163667.2
    Conserved Domains (1) summary
    pfam00307
    Location:265 → 365
    CH; Calponin homology (CH) domain

  2. NM_022321.4 → NP_071716.3  gamma-parvin isoform 2

    See identical proteins and their annotated locations for NP_071716.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK028329, AK079881, AL626769
    Consensus CDS
    CCDS27710.1
    UniProtKB/Swiss-Prot
    Q8BH45, Q91X89, Q9ERD8
    UniProtKB/TrEMBL
    Q8C2K9, Q8CEF2
    Related
    ENSMUSP00000023074.3, ENSMUST00000023074.9
    Conserved Domains (1) summary
    pfam00307
    Location:212 → 316
    CH; Calponin homology (CH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    84208388..84227179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245706.4 → XP_011244008.1  gamma-parvin isoform X1

    See identical proteins and their annotated locations for XP_011244008.1

    UniProtKB/Swiss-Prot
    Q8BH45, Q91X89, Q9ERD8
    UniProtKB/TrEMBL
    Q8C2K9, Q8CEF2
    Conserved Domains (1) summary
    pfam00307
    Location:212 → 316
    CH; Calponin homology (CH) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERD8.2 GenPept UniProtKB/Swiss-Prot:Q9ERD8

Gene LinkOut

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