gch2 GTP cyclohydrolase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gch2provided by ZNC
Official Full Name: GTP cyclohydrolase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-001205-3
See related: Ensembl:ENSDARG00000099101 AllianceGenome:ZFIN:ZDB-GENE-001205-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gch; gch1b; fb51g02; unm_vc44; camembert; wu:fb51g02
Summary: Predicted to enable GTP binding activity; GTP cyclohydrolase I activity; and zinc ion binding activity. Acts upstream of or within xanthophore differentiation. Predicted to be active in cytoplasm. Is expressed in head; neural crest; pigment cell; trunk; and xanthoblast. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (25085844..25092567)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (24994484..25001207)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fa01h05.s1 (e-PCR)
- UniSTS:202136

AI476841 (e-PCR)
- UniSTS:206550

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP cyclohydrolase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTP cyclohydrolase I activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in tetrahydrobiopterin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tetrahydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within xanthophore differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP cyclohydrolase 2

Names: GTP cyclohydrolase 1

NP_571742.1

EC 3.5.4.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131667.1 → NP_571742.1 GTP cyclohydrolase 2

See identical proteins and their annotated locations for NP_571742.1

Status: PROVISIONAL

Source sequence(s)

BC071298

UniProtKB/TrEMBL

A0A8M1PCK0, Q6IQV5

Related

ENSDARP00000130255.1, ENSDART00000170466.2

Conserved Domains (1) summary

cd00642
Location:55 → 238

GTP_cyclohydro1; GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In ...