U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MEIG1 meiosis/spermiogenesis associated 1 [ Homo sapiens (human) ]

Gene ID: 644890, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
MEIG1provided by HGNC
Official Full Name
meiosis/spermiogenesis associated 1provided by HGNC
Primary source
HGNC:HGNC:23429
See related
Ensembl:ENSG00000197889 MIM:614174; AllianceGenome:HGNC:23429
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPATA39; bA2K17.3
Summary
Predicted to be involved in cell differentiation. Predicted to act upstream of or within manchette assembly and protein localization. Predicted to be located in cytosol and manchette. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 4.2) and brain (RPKM 0.2) See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MEIG1 in Genome Data Viewer
Location:
10p13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (14954228..14988050)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (14968185..15002020)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15001387..15030049)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene SUV39H2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2164 Neighboring gene SUV39H2 histone lysine methyltransferase Neighboring gene NANOG hESC enhancer GRCh37_chr10:14946352-14947052 Neighboring gene DNA cross-link repair 1C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3086 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3087 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:14994732-14995460 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:14995461-14996188 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2166 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15033655-15034186 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:15034187-15034717 Neighboring gene olfactory receptor family 7 subfamily E member 110 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 26 pseudogene Neighboring gene olfactory receptor family 7 subfamily E member 115 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Germ cell-specific disruption of the Meig1 gene causes impaired spermiogenesis in mice. Teves ME, et al. Andrology, 2013 Jan. PMID 23258628, Free PMC Article
  2. Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding. Khan N, et al. Structure, 2021 Jun 3. PMID 33529594, Free PMC Article
  3. MEIG1 is essential for spermiogenesis in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805151, Free PMC Article
  4. Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility. Gupta N, et al. Andrologia, 2022 Oct. PMID 35768906
  5. Haploinsufficiency for the murine orthologue of Chlamydomonas PF20 disrupts spermatogenesis. Zhang Z, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15328412, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
    Title: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate with sperm motility in idiopathic infertility.
  2. Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.
    Title: Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in manchette assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in manchette IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
meiosis expressed gene 1 protein homolog
Names
meiosis expressed gene 1 homolog
spermatogenesis associated 39

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080836.3 → NP_001074305.1  meiosis expressed gene 1 protein homolog

    See identical proteins and their annotated locations for NP_001074305.1

    Status: VALIDATED

    Source sequence(s)
    AA971146, AI694434, AL360083, BG189536
    Consensus CDS
    CCDS31151.1
    UniProtKB/Swiss-Prot
    Q5JSS6
    Related
    ENSP00000384334.1, ENST00000407572.6
    Conserved Domains (1) summary
    pfam15163
    Location:11 → 86
    Meiosis_expr; Meiosis-expressed

RNA

  1. NR_147060.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL360083, BG189096, BX115809

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    14954228..14988050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448136.1 → XP_024303904.1  meiosis expressed gene 1 protein homolog isoform X1

    Conserved Domains (1) summary
    pfam15163
    Location:42 → 117
    Meiosis_expr; Meiosis-expressed

  2. XM_047425662.1 → XP_047281618.1  meiosis expressed gene 1 protein homolog isoform X2

    UniProtKB/Swiss-Prot
    Q5JSS6
    Related
    ENSP00000367486.1, ENST00000378240.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    14968185..15002020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366617.1 → XP_054222592.1  meiosis expressed gene 1 protein homolog isoform X1

  2. XM_054366618.1 → XP_054222593.1  meiosis expressed gene 1 protein homolog isoform X3

  3. XM_054366619.1 → XP_054222594.1  meiosis expressed gene 1 protein homolog isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_134493.1: Suppressed sequence

    Description
    NR_134493.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JSS6.1 GenPept UniProtKB/Swiss-Prot:Q5JSS6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools