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nrf1 nuclear respiratory factor 1 [ Danio rerio (zebrafish) ]

Gene ID: 64604, updated on 9-Dec-2024

Summary

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Official Symbol
nrf1provided by ZNC
Official Full Name
nuclear respiratory factor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-001221-1
See related
Ensembl:ENSDARG00000000018 AllianceGenome:ZFIN:ZDB-GENE-001221-1
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ube2h; SC:BZ3C13.1; SC:bZ3C13.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in neural retina development. Acts upstream of or within several processes, including cellular response to cold; photoreceptor cell maintenance; and response to activity. Predicted to be active in nucleus. Is expressed in heart; nervous system; optic cup; and visceral fat. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human NRF1 (nuclear respiratory factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See nrf1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (15081385..15103696, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (15082630..15104941, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene microRNA 96 Neighboring gene microRNA 182 Neighboring gene uncharacterized LOC137491395 Neighboring gene uncharacterized LOC137491533

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Sensing and responding to energetic stress: The role of the AMPK-PGC1α-NRF1 axis in control of mitochondrial biogenesis in fish. Bremer K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Sep. PMID 26393435
  2. Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio). Hasumura T, et al. J Comp Physiol B, 2016 Jul. PMID 26951149
  3. The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish. Chen D, et al. Int J Biochem Cell Biol, 2016 Aug. PMID 27184967
  4. Thyroid hormone actions are temperature-specific and regulate thermal acclimation in zebrafish (Danio rerio). Little AG, et al. BMC Biol, 2013 Mar 26. PMID 23531055, Free PMC Article
  5. Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis. Hiramitsu M, et al. Sci Rep, 2014 Jan 15. PMID 24424211, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within neural retina development IMP
Inferred from Mutant Phenotype
more info
  
involved_in neural retina development IMP
Inferred from Mutant Phenotype
more info
  
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina homeostasis IMP
Inferred from Mutant Phenotype
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear respiratory factor 1
Names
not really finished protein
nrf
nrf-1
nrl

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328540.1 → NP_001315469.1  nuclear respiratory factor 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL590150
    UniProtKB/Swiss-Prot
    O93570, Q7ZTS6, Q90X44
    Related
    ENSDARP00000149440.1, ENSDART00000181044.1
    Conserved Domains (2) summary
    pfam10492
    Location:461 → 514
    Nrf1_activ_bdg; Nrf1 activator activation site binding domain
    pfam10491
    Location:87 → 284
    Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

  2. NM_131680.2 → NP_571755.2  nuclear respiratory factor 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL590150
    UniProtKB/Swiss-Prot
    Q90X44
    Related
    ENSDARP00000116798.1, ENSDART00000138183.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    15081385..15103696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q90X44.2 GenPept UniProtKB/Swiss-Prot:Q90X44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.