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s1pr1 sphingosine-1-phosphate receptor 1 [ Danio rerio (zebrafish) ]

Gene ID: 64617, updated on 9-Dec-2024

Summary

Official Symbol
s1pr1provided by ZNC
Official Full Name
sphingosine-1-phosphate receptor 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-001228-2
See related
Ensembl:ENSDARG00000042690 AllianceGenome:ZFIN:ZDB-GENE-001228-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
edg1; s1p1; wu:fb98f05; etID43307.22
Summary
Enables lysophosphatidic acid receptor activity. Involved in G protein-coupled receptor signaling pathway. Acts upstream of or within several processes, including circulatory system development; mesodermal cell migration; and negative regulation of angiogenesis. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including cardiovascular system; fin bud; nervous system; neural tube; and pleuroperitoneal region. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See s1pr1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (16038488..16042243, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (16012218..16015973, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene serpin peptidase inhibitor, clade C (antithrombin), member 1 Neighboring gene zinc finger and BTB domain containing 37 Neighboring gene diphthamide biosynthesis 5 Neighboring gene solute carrier family 30 member 7

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables lysophosphatidic acid receptor activity IDA
Inferred from Direct Assay
more info
 
enables sphingosine-1-phosphate receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sphingosine-1-phosphate receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables sphingosine-1-phosphate receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesodermal cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingosine-1-phosphate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculature development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IC
Inferred by Curator
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
sphingosine 1-phosphate receptor 1
Names
S1P receptor 1
S1P receptor Edg-1
endothelial differentiation, sphingolipid G-protein-coupled receptor, 1
sphingosine 1-phosphate receptor Edg-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131691.3NP_571766.3  sphingosine 1-phosphate receptor 1

    Status: VALIDATED

    Source sequence(s)
    BX908392, EH440149, EH598427
    UniProtKB/Swiss-Prot
    Q6DI49, Q9DDK4
    UniProtKB/TrEMBL
    Q1LV63
    Related
    ENSDARP00000062632.3, ENSDART00000062633.4
    Conserved Domains (2) summary
    pfam00001
    Location:41292
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:35307
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    16038488..16042243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395099.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    346170..349925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395350.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    137869..141624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)