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Mrps10 mitochondrial ribosomal protein S10 [ Mus musculus (house mouse) ]

Gene ID: 64657, updated on 5-Mar-2024

Summary

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Official Symbol
Mrps10provided by MGI
Official Full Name
mitochondrial ribosomal protein S10provided by MGI
Primary source
MGI:MGI:1928139
See related
Ensembl:ENSMUSG00000034729 AllianceGenome:MGI:1928139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpms10; 1110038B19Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPS10 (mitochondrial ribosomal protein S10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.0), placenta adult (RPKM 2.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mrps10 in Genome Data Viewer
Location:
17 C; 17 23.0 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47679803..47692343)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (47368887..47381418)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:47276999-47277108 Neighboring gene predicted gene, 41589 Neighboring gene transcriptional regulating factor 1 Neighboring gene predicted gene, 36715 Neighboring gene STARR-seq mESC enhancer starr_42696 Neighboring gene STARR-seq mESC enhancer starr_42698 Neighboring gene STARR-seq mESC enhancer starr_42699 Neighboring gene STARR-seq mESC enhancer starr_42700 Neighboring gene guanylate cyclase activator 1B Neighboring gene guanylate cyclase activator 1a (retina) Neighboring gene Morf4 family associated protein 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
  2. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
  3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
  4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein uS10m
Names
28S ribosomal protein S10, mitochondrial
MRP-S10
S10mt
NP_001139683.1
NP_001139684.1
NP_898909.2
XP_011244868.1
XP_011244869.1
XP_030105834.1
XP_030105835.1
XP_030105836.1
XP_036016633.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146211.1 → NP_001139683.1  small ribosomal subunit protein uS10m isoform 2

    See identical proteins and their annotated locations for NP_001139683.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, that results in a protein (isoform 2) that is one amino acid shorter than isoform 1.
    Source sequence(s)
    BB862036, BC096043, DV046794
    Consensus CDS
    CCDS50130.1
    UniProtKB/TrEMBL
    G5E8U8, Q501J4
    Related
    ENSMUSP00000113460.2, ENSMUST00000120737.8
    Conserved Domains (1) summary
    pfam00338
    Location:77 → 171
    Ribosomal_S10; Ribosomal protein S10p/S20e

  2. NM_001146212.1 → NP_001139684.1  small ribosomal subunit protein uS10m isoform 1

    See identical proteins and their annotated locations for NP_001139684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK004151, BB862036, BC096043
    Consensus CDS
    CCDS50129.1
    UniProtKB/TrEMBL
    G5E8U5, Q501J4
    Related
    ENSMUSP00000113343.2, ENSMUST00000119945.8
    Conserved Domains (1) summary
    pfam00338
    Location:78 → 172
    Ribosomal_S10; Ribosomal protein S10p/S20e

  3. NM_183086.2 → NP_898909.2  small ribosomal subunit protein uS10m isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (3) has a shorter N-terminus when compared to isoform 1 and likely lacks a mitochondrial localization sequence.
    Source sequence(s)
    AC112683, BC096043
    Consensus CDS
    CCDS28846.1
    UniProtKB/Swiss-Prot
    Q4V9W5, Q80ZK0
    UniProtKB/TrEMBL
    E9QJS0
    Related
    ENSMUSP00000055301.7, ENSMUST00000060752.13
    Conserved Domains (1) summary
    pfam00338
    Location:37 → 131
    Ribosomal_S10; Ribosomal protein S10p/S20e

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    47679803..47692343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249975.2 → XP_030105835.1  small ribosomal subunit protein uS10m isoform X2

    UniProtKB/TrEMBL
    Q501J4
    Conserved Domains (1) summary
    pfam00338
    Location:75 → 170
    Ribosomal_S10; Ribosomal protein S10p/S20e

  2. XM_011246566.3 → XP_011244868.1  small ribosomal subunit protein uS10m isoform X3

    UniProtKB/TrEMBL
    Q501J4
    Conserved Domains (1) summary
    pfam00338
    Location:74 → 169
    Ribosomal_S10; Ribosomal protein S10p/S20e

  3. XM_011246567.4 → XP_011244869.1  small ribosomal subunit protein uS10m isoform X2

    UniProtKB/TrEMBL
    Q501J4
    Conserved Domains (1) summary
    pfam00338
    Location:75 → 170
    Ribosomal_S10; Ribosomal protein S10p/S20e

  4. XM_036160740.1 → XP_036016633.1  small ribosomal subunit protein uS10m isoform X2

    UniProtKB/TrEMBL
    Q501J4
    Conserved Domains (1) summary
    pfam00338
    Location:75 → 170
    Ribosomal_S10; Ribosomal protein S10p/S20e

  5. XM_030249976.2 → XP_030105836.1  small ribosomal subunit protein uS10m isoform X3

    UniProtKB/TrEMBL
    Q501J4
    Conserved Domains (1) summary
    pfam00338
    Location:74 → 169
    Ribosomal_S10; Ribosomal protein S10p/S20e

  6. XM_030249974.2 → XP_030105834.1  small ribosomal subunit protein uS10m isoform X1

    Conserved Domains (1) summary
    pfam00338
    Location:155 → 250
    Ribosomal_S10; Ribosomal protein S10p/S20e
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZK0.1 GenPept UniProtKB/Swiss-Prot:Q80ZK0

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