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Mrps25 mitochondrial ribosomal protein S25 [ Mus musculus (house mouse) ]

Gene ID: 64658, updated on 9-Dec-2024

Summary

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Official Symbol
Mrps25provided by MGI
Official Full Name
mitochondrial ribosomal protein S25provided by MGI
Primary source
MGI:MGI:1928140
See related
Ensembl:ENSMUSG00000014551 AllianceGenome:MGI:1928140
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rpms25; 2810429N01Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 50. Orthologous to human MRPS25 (mitochondrial ribosomal protein S25). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 14.0), cortex adult (RPKM 13.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Mrps25 in Genome Data Viewer
Location:
6 D1; 6 41.03 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (92146493..92161004, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (92169512..92184023, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E539 Neighboring gene nuclear receptor subfamily 2, group C, member 2 Neighboring gene predicted gene, 46967 Neighboring gene rabenosyn, RAB effector Neighboring gene STARR-seq mESC enhancer starr_16664 Neighboring gene thyrotropin releasing hormone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genes in the first and fourth inversions of the mouse t complex synergistically mediate sperm capacitation and interactions with the oocyte. Redkar AA, et al. Dev Biol, 2000 Oct 15. PMID 11023686
  2. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
  3. Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy. Chern T, et al. Nat Commun, 2022 Jan 10. PMID 35013307, Free PMC Article
  4. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. Koc EC, et al. J Biol Chem, 2000 Oct 20. PMID 10938081
  5. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within mitochondrial translation IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small ribosomal subunit protein mS25
Names
28S ribosomal protein S25, mitochondrial
MRP-S25
S25mt
NP_079854.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025578.4 → NP_079854.2  small ribosomal subunit protein mS25

    See identical proteins and their annotated locations for NP_079854.2

    Status: VALIDATED

    Source sequence(s)
    AC164642
    Consensus CDS
    CCDS20373.1
    UniProtKB/Swiss-Prot
    Q9CYY8, Q9D125
    UniProtKB/TrEMBL
    Q6KAU3
    Related
    ENSMUSP00000114402.2, ENSMUST00000140438.2
    Conserved Domains (1) summary
    smart00916
    Location:43 → 107
    L51_S25_CI-B8; Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    92146493..92161004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D125.1 GenPept UniProtKB/Swiss-Prot:Q9D125

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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