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SETSIP SET like protein [ Homo sapiens (human) ]

Gene ID: 646817, updated on 10-Dec-2024

Summary

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Official Symbol
SETSIPprovided by HGNC
Official Full Name
SET like proteinprovided by HGNC
Primary source
HGNC:HGNC:42937
See related
Ensembl:ENSG00000230667 AllianceGenome:HGNC:42937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SETP18
Summary
Enables chromatin binding activity. Involved in endothelial cell differentiation and positive regulation of transcription by RNA polymerase II. Located in cytoplasm; lipid droplet; and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See SETSIP in Genome Data Viewer
Location:
1p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (92074533..92075411, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (91919389..91920267, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (92540090..92540968, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:92495241-92495742 Neighboring gene epoxide hydrolase 4 Neighboring gene lysophosphatidylcholine acyltransferase 2b, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:92547175-92547842 Neighboring gene BTB domain containing 8 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 46 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit alpha pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Direct reprogramming of fibroblasts into endothelial cells capable of angiogenesis and reendothelialization in tissue-engineered vessels. Margariti A, et al. Proc Natl Acad Sci U S A, 2012 Aug 21. PMID 22869753, Free PMC Article
  2. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. Teachenor R, et al. Mol Cell Biol, 2012 May. PMID 22354994, Free PMC Article
  3. Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. Raisner R, et al. Cell Rep, 2018 Aug 14. PMID 30110629
  4. The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Weber LM, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36537216, Free PMC Article
  5. Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Han T, et al. Science, 2017 Apr 28. PMID 28302793

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endothelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein SETSIP
Names
SET nuclear oncogene pseudogene
SET pseudogene 18
SET pseudogene protein 18
SET similar protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287737.2 → NP_001274666.2  protein SETSIP

    Status: VALIDATED

    Source sequence(s)
    AC104836
    Consensus CDS
    CCDS72821.2
    UniProtKB/Swiss-Prot
    P0DME0
    Related
    ENSP00000480946.2, ENST00000596516.3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    92074533..92075411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    91919389..91920267 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_022728.1: Suppressed sequence

    Description
    NG_022728.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0DME0.2 GenPept UniProtKB/Swiss-Prot:P0DME0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials