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Nab1 Ngfi-A binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64824, updated on 17-Aug-2024

Summary

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Official Symbol
Nab1provided by RGD
Official Full Name
Ngfi-A binding protein 1provided by RGD
Primary source
RGD:70882
See related
EnsemblRapid:ENSRNOG00000012959 AllianceGenome:RGD:70882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be active in nucleus. Orthologous to human NAB1 (NGFI-A binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 141.6), Heart (RPKM 87.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (56545547..56585045)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (49053579..49093078)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (53906073..53945474)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency-associated protein 3-like Neighboring gene nuclear envelope integral membrane protein 2 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing striatal patches: role of dopamine and glutamate. Snyder-Keller A, et al. Brain Res, 2002 Dec 27. PMID 12470865
  2. Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain. Swirnoff AH, et al. Mol Cell Biol, 1998 Jan. PMID 9418898, Free PMC Article
  3. Active gene repression by the Egr2.NAB complex during peripheral nerve myelination. Mager GM, et al. J Biol Chem, 2008 Jun 27. PMID 18456662, Free PMC Article
  4. Nab proteins are essential for peripheral nervous system myelination. Le N, et al. Nat Neurosci, 2005 Jul. PMID 16136673
  5. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Russo MW, et al. Proc Natl Acad Sci U S A, 1995 Jul 18. PMID 7624335, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Egr2 directly represses genes during myelination in conjunction with NAB corepressors
    Title: Active gene repression by the Egr2.NAB complex during peripheral nerve myelination.
  2. NGFI-A protein expression in the developing striatum appears to be driven first by dopaminergic afferents, and then later in development by excitatory glutamatergic afferents.
    Title: Basal EGR-1 (zif268, NGFI-A, Krox-24) expression in developing striatal patches: role of dopamine and glutamate.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endochondral ossification ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within myelination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of epidermis development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NGFI-A-binding protein 1
Names
EGR-1-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022856.5 → NP_074047.2  NGFI-A-binding protein 1

    See identical proteins and their annotated locations for NP_074047.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q62722
    UniProtKB/TrEMBL
    A0A8I5XW60, A6INW5
    Related
    ENSRNOP00000077471.1, ENSRNOT00000106868.2
    Conserved Domains (3) summary
    pfam04902
    Location:321 → 484
    Nab1; Conserved region in Nab1
    pfam04904
    Location:5 → 83
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:190 → 316
    NCD2; NAB conserved region 2 (NCD2)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    56545547..56585045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084187.2 → XP_038940115.1  NGFI-A-binding protein 1 isoform X2

    Conserved Domains (2) summary
    pfam04904
    Location:5 → 83
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:190 → 273
    NCD2; NAB conserved region 2 (NCD2)

  2. XM_039084185.2 → XP_038940113.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q62722
    UniProtKB/TrEMBL
    A0A8I5XW60, A6INW5
    Conserved Domains (3) summary
    pfam04902
    Location:321 → 484
    Nab1; Conserved region in Nab1
    pfam04904
    Location:5 → 83
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:190 → 316
    NCD2; NAB conserved region 2 (NCD2)

  3. XM_039084186.2 → XP_038940114.1  NGFI-A-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q62722
    UniProtKB/TrEMBL
    A0A8I5XW60, A6INW5
    Related
    ENSRNOP00000017813.5, ENSRNOT00000017813.9
    Conserved Domains (3) summary
    pfam04902
    Location:321 → 484
    Nab1; Conserved region in Nab1
    pfam04904
    Location:5 → 83
    NCD1; NAB conserved region 1 (NCD1)
    pfam04905
    Location:190 → 316
    NCD2; NAB conserved region 2 (NCD2)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62722.2 GenPept UniProtKB/Swiss-Prot:Q62722

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