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AIDA axin interactor, dorsalization associated [ Homo sapiens (human) ]

Gene ID: 64853, updated on 10-Dec-2024

Summary

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Official Symbol
AIDAprovided by HGNC
Official Full Name
axin interactor, dorsalization associatedprovided by HGNC
Primary source
HGNC:HGNC:25761
See related
Ensembl:ENSG00000186063 MIM:612375; AllianceGenome:HGNC:25761
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C1orf80
Summary
Predicted to enable phosphatidylinositol binding activity. Acts upstream of or within negative regulation of JUN kinase activity. Predicted to be located in cytoplasm. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in fat (RPKM 42.6), testis (RPKM 31.5) and 25 other tissues See more
Orthologs
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Genomic context

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See AIDA in Genome Data Viewer
Location:
1q41
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222668013..222712491, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (221901757..221946247, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222841355..222885833, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222763242-222763775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:222763776-222764308 Neighboring gene TAF1A antisense RNA 1 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:222791257-222792139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2577 Neighboring gene MIA SH3 domain ER export factor 3 Neighboring gene prefoldin subunit 5-like Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr1:222816645-222817522 and GRCh37_chr1:222817523-222818398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2581 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5183 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:222885601-222886515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5205 Neighboring gene BRO1 domain and CAAX motif containing Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:222909786-222910327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene family with sequence similarity 177 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene. Lalonde S, et al. Genome Biol, 2019 Jul 8. PMID 31287004, Free PMC Article
  2. MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation. Zhang P, et al. Int Heart J, 2022. PMID 36184552
  3. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Rui Y, et al. Dev Cell, 2007 Aug. PMID 17681137
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. Butland SL, et al. Hum Mol Genet, 2014 Aug 1. PMID 24705354, Free PMC Article
  5. Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Zang W, et al. Proc Natl Acad Sci U S A, 2019 Dec 17. PMID 31796584, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation.
    Title: MiR-32-5p/AIDA Mediates OxLDL-Induced Endothelial Injury and Inflammation.
  2. genetic variant acts in the vascular endothelium to modulate inter-individual risk in coronary artery disease
    Title: Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12806, FLJ32421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in determination of ventral identity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dorsal/ventral pattern formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
axin interactor, dorsalization-associated protein
Names
axin interaction partner and dorsalization antagonist

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022831.4 → NP_073742.2  axin interactor, dorsalization-associated protein

    See identical proteins and their annotated locations for NP_073742.2

    Status: VALIDATED

    Source sequence(s)
    AL392172, AL592148
    Consensus CDS
    CCDS1533.1
    UniProtKB/Swiss-Prot
    A8K1F0, Q49A81, Q5JRA4, Q658P1, Q96BJ3, Q9H9E8
    UniProtKB/TrEMBL
    B7ZW30
    Related
    ENSP00000339161.6, ENST00000340020.11
    Conserved Domains (2) summary
    pfam08910
    Location:9 → 112
    Aida_N; Aida N-terminus
    pfam14186
    Location:162 → 300
    Aida_C2; Cytoskeletal adhesion

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    222668013..222712491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428100.1 → XP_047284056.1  axin interactor, dorsalization-associated protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    221901757..221946247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338316.1 → XP_054194291.1  axin interactor, dorsalization-associated protein isoform X2

  2. XM_054338315.1 → XP_054194290.1  axin interactor, dorsalization-associated protein isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96BJ3.1 GenPept UniProtKB/Swiss-Prot:Q96BJ3

Gene LinkOut

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