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Lrp10 low-density lipoprotein receptor-related protein 10 [ Mus musculus (house mouse) ]

Gene ID: 65107, updated on 9-Dec-2024

Summary

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Official Symbol
Lrp10provided by MGI
Official Full Name
low-density lipoprotein receptor-related protein 10provided by MGI
Primary source
MGI:MGI:1929480
See related
Ensembl:ENSMUSG00000022175 AllianceGenome:MGI:1929480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrp9
Summary
Enables low-density lipoprotein particle receptor activity. Acts upstream of or within inner ear development; lipid metabolic process; and lipid transport. Located in membrane. Is expressed in several structures, including adrenal gland; brain; genitourinary system; liver; and meninges. Orthologous to human LRP10 (LDL receptor related protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in colon adult (RPKM 199.5), adrenal adult (RPKM 148.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Lrp10 in Genome Data Viewer
Location:
14 C2; 14 27.8 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54701260..54707749)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54464137..54470292)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 14 (membrane-inserted) Neighboring gene STARR-positive B cell enhancer mm9_chr14:55067911-55068211 Neighboring gene STARR-seq mESC enhancer starr_36736 Neighboring gene predicted gene, 24424 Neighboring gene STARR-positive B cell enhancer ABC_E8559 Neighboring gene STARR-positive B cell enhancer ABC_E5436 Neighboring gene rad and gem related GTP binding protein 2 Neighboring gene predicted gene, 41153

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Intracellular trafficking of LRP9 is dependent on two acidic cluster/dileucine motifs. Boucher R, et al. Histochem Cell Biol, 2008 Aug. PMID 18461348
  2. Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family. Jeong YH, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 20005200
  3. Calnuc binds to LRP9 and affects its endosomal sorting. Brodeur J, et al. Traffic, 2009 Aug. PMID 19497050
  4. A novel low-density lipoprotein receptor-related protein mediating cellular uptake of apolipoprotein E-enriched beta-VLDL in vitro. Sugiyama T, et al. Biochemistry, 2000 Dec 26. PMID 11123907
  5. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Pons S, et al. Mol Cell Biol, 1995 Aug. PMID 7542745, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables low-density lipoprotein particle receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-density lipoprotein particle receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inner ear development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 10
Names
LRP-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022993.3 → NP_075369.2  low-density lipoprotein receptor-related protein 10 precursor

    See identical proteins and their annotated locations for NP_075369.2

    Status: VALIDATED

    Source sequence(s)
    BC052378, CAAA01001439
    Consensus CDS
    CCDS27089.1
    UniProtKB/Swiss-Prot
    Q3UNT0, Q7TQH7, Q7TS95, Q921T0, Q9EPE8
    UniProtKB/TrEMBL
    Q3TD85, Q3V1Z1
    Related
    ENSMUSP00000022782.9, ENSMUST00000022782.10
    Conserved Domains (2) summary
    cd00041
    Location:193 → 303
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:141 → 175
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54701260..54707749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519358.3 → XP_006519421.1  low-density lipoprotein receptor-related protein 10 isoform X1

    UniProtKB/TrEMBL
    Q3TD85, Q3V1Z1
    Conserved Domains (3) summary
    cd00041
    Location:68 → 178
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:16 → 50
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam12999
    Location:219 → 269
    PRKCSH-like; Glucosidase II beta subunit-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQH7.2 GenPept UniProtKB/Swiss-Prot:Q7TQH7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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