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prss1 serine protease 1 [ Danio rerio (zebrafish) ]

Gene ID: 65223, updated on 22-Dec-2024

Summary

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Official Symbol
prss1provided by ZNC
Official Full Name
serine protease 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-010131-7
See related
Ensembl:ENSDARG00000042993 AllianceGenome:ZFIN:ZDB-GENE-010131-7
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
try; wu:fb57g08; zgc:109701
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in acinar cell; brain; digestive system; exocrine cell; and heart. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to several human genes including PRSS1 (serine protease 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See prss1 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (25080759..25085306, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (25165727..25170274, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 1035 Neighboring gene im:7147486 Neighboring gene si:ch211-261d7.3 Neighboring gene zgc:66448

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Biochemical characterization of zebrafish Prss59.1. Rana R, et al. Biochem Biophys Res Commun, 2021 Jun 30. PMID 33965786
  2. Pancreas development in zebrafish: early dispersed appearance of endocrine hormone expressing cells and their convergence to form the definitive islet. Biemar F, et al. Dev Biol, 2001 Feb 15. PMID 11161572
  3. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Stafford D, et al. Curr Biol, 2002 Jul 23. PMID 12176331
  4. Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Field HA, et al. Dev Biol, 2003 Sep 1. PMID 12941629
  5. Origin and determination of inhibitory cell lineages in the vertebrate retina. Jusuf PR, et al. J Neurosci, 2011 Feb 16. PMID 21325522, Free PMC Article

See all (156) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109701

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
trypsin-1
Names
protease, serine 1
trypsin
trypsinogen 2
NP_571783.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131708.2 → NP_571783.2  trypsin-1 precursor

    See identical proteins and their annotated locations for NP_571783.2

    Status: VALIDATED

    Source sequence(s)
    BX539313, EH490900, EH517238
    UniProtKB/TrEMBL
    B2GTK8, Q561Z7
    Related
    ENSDARP00000072127.5, ENSDART00000077661.7
    Conserved Domains (2) summary
    smart00020
    Location:24 → 240
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25 → 243
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    25080759..25085306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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