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ctbp2a C-terminal binding protein 2a [ Danio rerio (zebrafish) ]

Gene ID: 65230, updated on 4-Jan-2025

Summary

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Official Symbol
ctbp2aprovided by ZNC
Official Full Name
C-terminal binding protein 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010130-2
See related
Ensembl:ENSDARG00000044062 AllianceGenome:ZFIN:ZDB-GENE-010130-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ctbp2; fe05b01; wu:fb96g03; wu:fe05b01; wu:fk19e02
Summary
Predicted to enable DNA-binding transcription factor binding activity; transcription coregulator activity; and transcription coregulator binding activity. Acts upstream of or within several processes, including nervous system development; regulation of gliogenesis; and regulation of melanocyte differentiation. Predicted to be active in nucleus. Is expressed in nervous system; neural plate; otic vesicle; pectoral fin; and pharyngeal arch. Orthologous to human CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ctbp2a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (8596943..8727731, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (8439763..8535542, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 3b Neighboring gene keratinocyte associated protein 3 Neighboring gene testis expressed 36 Neighboring gene erythroid differentiation regulatory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spectral inference reveals principal cone-integration rules of the zebrafish inner retina. Bartel P, et al. Curr Biol, 2021 Dec 6. PMID 34653362, Free PMC Article
  2. Computational processing of optical measurements of neuronal and synaptic activity in networks. Dorostkar MM, et al. J Neurosci Methods, 2010 Apr 30. PMID 20152860, Free PMC Article
  3. Rapid mapping of visual receptive fields by filtered back projection: application to multi-neuronal electrophysiology and imaging. Johnston J, et al. J Physiol, 2014 Nov 15. PMID 25172952, Free PMC Article
  4. Stereotyped initiation of retinal waves by bipolar cells via presynaptic NMDA autoreceptors. Zhang RW, et al. Nat Commun, 2016 Sep 2. PMID 27586999, Free PMC Article
  5. Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio). Muraoka O, et al. Dev Biol, 2000 Dec 1. PMID 11087624

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ribeye makes up most of the synaptic ribbon density in neuromast hair cells and is necessary for proper localization of calcium channels and synaptic ribbons.
    Title: Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.
  2. In photoreceptor cells, RIBEYE and RIM2 are expressed along the synaptic ribbon.
    Title: High-resolution optical imaging of zebrafish larval ribbon synapse protein RIBEYE, RIM2, and CaV 1.4 by stimulation emission depletion microscopy.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC191960

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within clustering of voltage-gated calcium channels IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gliogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synapse assembly involved in innervation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
C-terminal-binding protein 2a
Names
C-terminal binding protein 2
riba
ribeye a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195491.2 → NP_001182420.2  C-terminal-binding protein 2a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    CU459182
    UniProtKB/TrEMBL
    Q5BU19
    Related
    ENSDARP00000124211.1, ENSDART00000148504.3

  2. NM_131715.2 → NP_571790.1  C-terminal-binding protein 2a isoform 2

    See identical proteins and their annotated locations for NP_571790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1, resulting in a protein that is shorter and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    CU459182
    UniProtKB/TrEMBL
    A0A8N1Z1U1, Q9DEG6
    Related
    ENSDARP00000123977.1, ENSDART00000148931.3
    Conserved Domains (2) summary
    COG0111
    Location:50 → 360
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:34 → 352
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    8596943..8727731 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214450.1 → XP_068070551.1  C-terminal-binding protein 2a isoform X7

    UniProtKB/TrEMBL
    A0A8N1Z1U1, Q9DEG6
    Related
    ENSDARP00000124751.1, ENSDART00000148827.3

  2. XM_068214449.1 → XP_068070550.1  C-terminal-binding protein 2a isoform X7

    UniProtKB/TrEMBL
    A0A8N1Z1U1, Q9DEG6
    Related
    ENSDARP00000124822.1, ENSDART00000149505.3

  3. XM_068214451.1 → XP_068070552.1  C-terminal-binding protein 2a isoform X7

    UniProtKB/TrEMBL
    A0A8N1Z1U1, Q9DEG6
    Related
    ENSDARP00000049235.7, ENSDART00000049236.9

  4. XM_068214447.1 → XP_068070548.1  C-terminal-binding protein 2a isoform X5

    Related
    ENSDARP00000017286.7, ENSDART00000012546.9

  5. XM_068214443.1 → XP_068070544.1  C-terminal-binding protein 2a isoform X1

    UniProtKB/TrEMBL
    Q5BU19
    Related
    ENSDARP00000134141.2, ENSDART00000171850.2

  6. XM_068214445.1 → XP_068070546.1  C-terminal-binding protein 2a isoform X3

    UniProtKB/TrEMBL
    Q5BU19
    Related
    ENSDARP00000148839.1, ENSDART00000192714.1

  7. XM_068214444.1 → XP_068070545.1  C-terminal-binding protein 2a isoform X2

    UniProtKB/TrEMBL
    Q5BU19

  8. XM_068214446.1 → XP_068070547.1  C-terminal-binding protein 2a isoform X4

    UniProtKB/TrEMBL
    Q5BU19

  9. XM_068214448.1 → XP_068070549.1  C-terminal-binding protein 2a isoform X6

  10. XM_068214452.1 → XP_068070553.1  C-terminal-binding protein 2a isoform X8

Nucleotide Protein Strain
Heading Accession and Version

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