U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BMPR1A bone morphogenetic protein receptor type 1A [ Homo sapiens (human) ]

Gene ID: 657, updated on 10-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
BMPR1Aprovided by HGNC
Official Full Name
bone morphogenetic protein receptor type 1Aprovided by HGNC
Primary source
HGNC:HGNC:1076
See related
Ensembl:ENSG00000107779 MIM:601299; AllianceGenome:HGNC:1076
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALK3; SKR5; ALK-3; CD292; ACVRLK3; BMPR-1A; 10q23del
Summary
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 14.8), endometrium (RPKM 10.0) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See BMPR1A in Genome Data Viewer
Location:
10q23.2
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (86755763..86932844)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (87639833..87816596)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (88515520..88692601)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3695 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:88433149-88433337 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_17910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88441665-88442166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88442167-88442666 Neighboring gene VISTA enhancer hs2143 Neighboring gene opsin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88459642-88460142 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88460143-88460643 Neighboring gene LIM domain binding 3 Neighboring gene hESC enhancers GRCh37_chr10:88470545-88471164 and GRCh37_chr10:88471165-88471784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2573 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:88552774-88553500 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:88597221-88597813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88615649-88616230 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88624164-88624816 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88624817-88625468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88627361-88627948 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88631460-88632021 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3697 Neighboring gene RNA polymerase II associated protein 2 pseudogene 1 Neighboring gene RNA, U1 small nuclear 19, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88700126-88700626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88704401-88704974 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88713843-88714442 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88715044-88715643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88718646-88719245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:88720446-88721046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88721647-88722246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3699 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3700 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88726172-88726925 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:88726926-88727678 Neighboring gene Sharpr-MPRA regulatory region 6517 Neighboring gene multimerin 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:88730527-88731726 Neighboring gene ADIRF antisense RNA 1 Neighboring gene synuclein gamma Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 11 Neighboring gene adipogenesis regulatory factor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BMPR1A mutations in juvenile polyposis affect cellular localization. Howe JR, et al. J Surg Res, 2013 Oct. PMID 23433720, Free PMC Article
  2. Discovery of the BMPR1A promoter and germline mutations that cause juvenile polyposis. Calva-Cerqueira D, et al. Hum Mol Genet, 2010 Dec 1. PMID 20843829, Free PMC Article
  3. BMPRIA is a promising marker for evaluating ganglion cells in the enteric nervous system--a pilot study. Brewer KC, et al. Hum Pathol, 2005 Oct. PMID 16226113
  4. BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency. Nieminen TT, et al. Gastroenterology, 2011 Jul. PMID 21640116
  5. Variable Features of Juvenile Polyposis Syndrome With Gastric Involvement Among Patients With a Large Genomic Deletion of BMPR1A. Lieberman S, et al. Clin Transl Gastroenterol, 2019 Jul. PMID 31259752, Free PMC Article

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Nonsense suppression induces read-through of a novel BMPR1A variant in a Chinese family with hereditary colorectal cancer.
    Title: Nonsense suppression induces read-through of a novel BMPR1A variant in a Chinese family with hereditary colorectal cancer.
  2. ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer.
    Title: ZEB1-AS1 mediates bone metastasis through targeting miR-320b/BMPR1A axis in lung cancer.
  3. Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
    Title: Hsa-miR-27b-5p suppresses the osteogenic and odontogenic differentiation of stem cells from human exfoliated deciduous teeth via targeting BMPR1A: An ex vivo study.
  4. Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers.
    Title: Adenomatous Polyposis Phenotype in BMPR1A and SMAD4 Variant Carriers.
  5. Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
    Title: Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation.
  6. Bone morphogenetic protein receptor 1alpha promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis.
    Title: Bone morphogenetic protein receptor 1α promotes osteolytic lesion of oral squamous cell carcinoma by SHH-dependent osteoclastogenesis.
  7. BMP4/ALK3 deficiency leads to Meckel's cartilage truncation mimicking the mandible Tessier 30 cleft.
    Title: BMP4/ALK3 deficiency leads to Meckel's cartilage truncation mimicking the mandible Tessier 30 cleft.
  8. Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant.
    Title: Phenotypic Differences in Juvenile Polyposis Syndrome With or Without a Disease-causing SMAD4/BMPR1A Variant.
  9. Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERalpha levels.
    Title: Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels.
  10. Anti-Mullerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival.
    Title: Anti-Müllerian hormone concentration regulates activin receptor-like kinase-2/3 expression levels with opposing effects on ovarian cancer cell survival.
Submit: New GeneRIF Correction See all GeneRIFs (90)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Juvenile polyposis syndrome
MedGen: C0345893 OMIM: 174900 GeneReviews: Juvenile Polyposis Syndrome
Compare labs
Polyposis syndrome, hereditary mixed, 2
MedGen: C1864730 OMIM: 610069 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2020-06-24)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2020-06-24)

ClinGen Genome Curation PagePubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of pulmonary arterial smooth muscle cells with HIV-1 gp120 downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins PubMed
Nef nef Treatment of pulmonary arterial smooth muscle cells with HIV-1 Nef downregulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins PubMed
Tat tat Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat modulates expression of BMPR-2, BMPR-1A, and BMPR-1B proteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables BMP binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables BMP receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables BMP receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables SMAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables activin receptor activity, type I IEA
Inferred from Electronic Annotation
more info
  
enables activin receptor activity, type II IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transforming growth factor beta receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transforming growth factor beta receptor activity, type I IDA
Inferred from Direct Assay
more info
 PubMed 
enables transforming growth factor beta receptor activity, type II IEA
Inferred from Electronic Annotation
more info
  
enables transforming growth factor beta receptor activity, type III IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane receptor protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in BMP signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in BMP signaling pathway TAS
Traceable Author Statement
more info
  
involved_in Mullerian duct regression IEA
Inferred from Electronic Annotation
more info
  
involved_in activin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in atrioventricular node cell development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in atrioventricular valve development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac conduction system development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cardiac right ventricle morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to BMP stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system neuron differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in developmental growth IEA
Inferred from Electronic Annotation
more info
  
involved_in dorsal aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in dorsal/ventral axis specification IEA
Inferred from Electronic Annotation
more info
  
involved_in dorsal/ventral pattern formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ectoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocardial cushion formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endocardial cushion morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in fibrous ring of heart morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in heart formation IEA
Inferred from Electronic Annotation
more info
  
involved_in hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in lateral mesoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in lung development IEA
Inferred from Electronic Annotation
more info
  
involved_in mesendoderm development IEA
Inferred from Electronic Annotation
more info
  
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitral valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural crest cell development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural plate mediolateral regionalization IEA
Inferred from Electronic Annotation
more info
  
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in outflow tract septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in paraxial mesoderm structural organization IEA
Inferred from Electronic Annotation
more info
  
involved_in pharyngeal arch artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in pituitary gland development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of SMAD protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of cardiac ventricle development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of dendrite development TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of miRNA transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in regulation of cardiac muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cellular senescence IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of lateral mesodermal cell fate specification IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in regulation of neural crest cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in roof of mouth development IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in somitogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tricuspid valve morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventricular compact myocardium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ventricular trabecula myocardium morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of HFE-transferrin receptor complex IC
Inferred by Curator
more info
 PubMed 
colocalizes_with caveola IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
bone morphogenetic protein receptor type-1A
Names
BMP type-1A receptor
activin A receptor, type II-like kinase 3
activin receptor-like kinase 3
bone morphogenetic protein receptor, type IA
serine/threonine-protein kinase receptor R5
NP_001393488.1
NP_001393489.1
NP_001393490.1
NP_001393491.1
NP_001393492.1
NP_001393493.1
NP_001393494.1
NP_001393495.1
NP_001393496.1
NP_001393497.1
NP_001393498.1
NP_001393499.1
NP_001393500.1
NP_001393501.1
NP_001393502.1
NP_001393503.1
NP_001393504.1
NP_001393505.1
NP_001393506.1
NP_001393507.1
NP_001393508.1
NP_001393509.1
NP_001393510.1
NP_001393511.1
NP_001393512.1
NP_001393513.1
NP_001393514.1
NP_001393515.1
NP_001393516.1
NP_001393517.1
NP_001393518.1
NP_004320.2
XP_047281636.1
XP_054222620.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009362.1 RefSeqGene

    Range
    5001..173550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_298

mRNA and Protein(s)

  1. NM_001406559.1 → NP_001393488.1  bone morphogenetic protein receptor type-1A isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  2. NM_001406560.1 → NP_001393489.1  bone morphogenetic protein receptor type-1A isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  3. NM_001406561.1 → NP_001393490.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9
    Related
    ENSP00000483569.2, ENST00000480152.3

  4. NM_001406562.1 → NP_001393491.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  5. NM_001406563.1 → NP_001393492.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  6. NM_001406564.1 → NP_001393493.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  7. NM_001406565.1 → NP_001393494.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  8. NM_001406566.1 → NP_001393495.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  9. NM_001406567.1 → NP_001393496.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  10. NM_001406568.1 → NP_001393497.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9
    Related
    ENSP00000518971.1, ENST00000713669.1

  11. NM_001406569.1 → NP_001393498.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  12. NM_001406570.1 → NP_001393499.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  13. NM_001406571.1 → NP_001393500.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  14. NM_001406572.1 → NP_001393501.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  15. NM_001406573.1 → NP_001393502.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  16. NM_001406574.1 → NP_001393503.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  17. NM_001406575.1 → NP_001393504.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  18. NM_001406576.1 → NP_001393505.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  19. NM_001406577.1 → NP_001393506.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  20. NM_001406578.1 → NP_001393507.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9
    Related
    ENSP00000518977.1, ENST00000713675.1

  21. NM_001406579.1 → NP_001393508.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  22. NM_001406580.1 → NP_001393509.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  23. NM_001406581.1 → NP_001393510.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  24. NM_001406582.1 → NP_001393511.1  bone morphogenetic protein receptor type-1A isoform 3 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

  25. NM_001406583.1 → NP_001393512.1  bone morphogenetic protein receptor type-1A isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  26. NM_001406584.1 → NP_001393513.1  bone morphogenetic protein receptor type-1A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  27. NM_001406585.1 → NP_001393514.1  bone morphogenetic protein receptor type-1A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  28. NM_001406586.1 → NP_001393515.1  bone morphogenetic protein receptor type-1A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  29. NM_001406587.1 → NP_001393516.1  bone morphogenetic protein receptor type-1A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9

  30. NM_001406588.1 → NP_001393517.1  bone morphogenetic protein receptor type-1A isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    UniProtKB/TrEMBL
    B5BUG9
    Related
    ENSP00000518975.1, ENST00000713673.1

  31. NM_001406589.1 → NP_001393518.1  bone morphogenetic protein receptor type-1A isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750

  32. NM_004329.3 → NP_004320.2  bone morphogenetic protein receptor type-1A isoform 3 precursor

    See identical proteins and their annotated locations for NP_004320.2

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750
    Consensus CDS
    CCDS7378.1
    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9
    Related
    ENSP00000361107.2, ENST00000372037.8
    Conserved Domains (3) summary
    smart00221
    Location:234 → 521
    STYKc; Protein kinase; unclassified specificity
    cd14220
    Location:238 → 524
    STKc_BMPR1a; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor
    pfam01064
    Location:59 → 138
    Activin_recp; Activin types I and II receptor domain

RNA

  1. NR_176211.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750

  2. NR_176212.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750

  3. NR_176213.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC021036, AC025268, AC067750

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    86755763..86932844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425680.1 → XP_047281636.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    87639833..87816596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366645.1 → XP_054222620.1  bone morphogenetic protein receptor type-1A isoform X1

    UniProtKB/Swiss-Prot
    A8K6U9, P36894, Q8NEN8
    UniProtKB/TrEMBL
    B5BUG9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36894.2 GenPept UniProtKB/Swiss-Prot:P36894

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Medical
Molecular Biology Databases
Research Materials
Tools
Miscellaneous