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Cep20 centrosomal protein 20 [ Mus musculus (house mouse) ]

Gene ID: 66086, updated on 28-Oct-2024

Summary

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Official Symbol
Cep20provided by MGI
Official Full Name
centrosomal protein 20provided by MGI
Primary source
MGI:MGI:1913336
See related
Ensembl:ENSMUSG00000022677 AllianceGenome:MGI:1913336
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fopnl; 0610037P05Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in cilium assembly. Located in ciliary basal body and motile cilium. Is expressed in several structures, including central nervous system; heart; liver; lung; and spleen. Orthologous to human CEP20 (centrosomal protein 20). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 10.8), genital fat pad adult (RPKM 9.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cep20 in Genome Data Viewer
Location:
16 A1; 16 9.74 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (14117105..14136093, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (14299241..14318229, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4155 Neighboring gene STARR-seq mESC enhancer starr_40176 Neighboring gene nudE neurodevelopment protein 1 Neighboring gene myosin, heavy polypeptide 11, smooth muscle Neighboring gene STARR-seq mESC enhancer starr_40179 Neighboring gene STARR-seq mESC enhancer starr_40180 Neighboring gene STARR-seq mESC enhancer starr_40183 Neighboring gene ATP-binding cassette, sub-family C member 1 Neighboring gene predicted gene, 23116 Neighboring gene STARR-seq mESC enhancer starr_40186 Neighboring gene RIKEN cDNA A630010A05 gene Neighboring gene STARR-seq mESC enhancer starr_40188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Centrosomal protein FOR20 knockout mice display embryonic lethality and left-right patterning defects. Xu Z, et al. FEBS Lett, 2021 May. PMID 33686659
  2. Control of ciliogenesis by FOR20, a novel centrosome and pericentriolar satellite protein. Sedjaï F, et al. J Cell Sci, 2010 Jul 15. PMID 20551181
  3. A centrosomal protein FOR20 regulates microtubule assembly dynamics and plays a role in cell migration. Srivastava S, et al. Biochem J, 2017 Aug 10. PMID 28694353
  4. A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling. Fujitani M, et al. Mol Psychiatry, 2017 Mar. PMID 27378146, Free PMC Article
  5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule anchoring IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
centrosomal protein 20
Names
FGFR1OP N-terminal-like protein
FOP-related protein of 20 kDa
Fgfr1op N-terminal like
lisH domain-containing protein C16orf63 homolog
lisH domain-containing protein FOPNL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025345.2 → NP_079621.1  centrosomal protein 20

    See identical proteins and their annotated locations for NP_079621.1

    Status: PROVISIONAL

    Source sequence(s)
    BC011300
    Consensus CDS
    CCDS27973.1
    UniProtKB/Swiss-Prot
    Q3UIK2, Q9CZS3
    Related
    ENSMUSP00000023357.8, ENSMUST00000023357.14
    Conserved Domains (1) summary
    pfam09398
    Location:43 → 113
    FOP_dimer; FOP N terminal dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    14117105..14136093 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522450.4 → XP_006522513.1  centrosomal protein 20 isoform X1

    Conserved Domains (1) summary
    cl29685
    Location:3 → 47
    LisH_2

  2. XM_017317110.2 → XP_017172599.1  centrosomal protein 20 isoform X2

    Conserved Domains (1) summary
    cl29685
    Location:43 → 98
    LisH_2

RNA

  1. XR_001781849.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZS3.1 GenPept UniProtKB/Swiss-Prot:Q9CZS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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