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Arfgap3 ADP-ribosylation factor GTPase activating protein 3 [ Mus musculus (house mouse) ]

Gene ID: 66251, updated on 11-Apr-2024

Summary

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Official Symbol
Arfgap3provided by MGI
Official Full Name
ADP-ribosylation factor GTPase activating protein 3provided by MGI
Primary source
MGI:MGI:1913501
See related
Ensembl:ENSMUSG00000054277 AllianceGenome:MGI:1913501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arfgap1; 0610009H19Rik; 1810004P07Rik; 1810035F16Rik; 9130416J18Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in COPI coating of Golgi vesicle. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in Golgi apparatus and cytosol. Orthologous to human ARFGAP3 (ADP ribosylation factor GTPase activating protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 30.0), colon adult (RPKM 25.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arfgap3 in Genome Data Viewer
Location:
15 E1; 15 39.4 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83183940..83234576, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83299739..83350375, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130064B19 gene Neighboring gene STARR-seq mESC enhancer starr_39326 Neighboring gene predicted gene, 32788 Neighboring gene STARR-seq mESC enhancer starr_39329 Neighboring gene RIKEN cDNA 1700001L05 gene Neighboring gene microRNA 12186 Neighboring gene protein kinase C and casein kinase substrate in neurons 2 Neighboring gene predicted gene, 41368

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Effects of mechanical trauma on the differentiation and ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle. Yi Y, et al. Int Urogynecol J, 2020 Sep. PMID 31989201
  2. ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis. Dembla M, et al. J Neurosci, 2014 Apr 9. PMID 24719103, Free PMC Article
  3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of mechanical trauma on the differentiation and ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle.
    Title: Effects of mechanical trauma on the differentiation and ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle.
  2. ArfGAP3 interacts with RIBEYE in an NAD(H)-dependent manner.
    Title: ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in COPI coating of Golgi vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in presynaptic endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor ribbon synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ADP-ribosylation factor GTPase-activating protein 3
Names
ADP-ribosylation factor GTPase activating protein 1
ARF GAP 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357756.1 → NP_001344685.1  ADP-ribosylation factor GTPase-activating protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC165945
    Conserved Domains (2) summary
    smart00105
    Location:13 → 116
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    pfam09507
    Location:134 → 292
    CDC27; DNA polymerase subunit Cdc27

  2. NM_001357757.1 → NP_001344686.1  ADP-ribosylation factor GTPase-activating protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC165945
    Consensus CDS
    CCDS88818.1
    UniProtKB/Swiss-Prot
    Q544V6, Q8BW06, Q99KN8, Q9D8S3
    Related
    ENSMUSP00000154712.2, ENSMUST00000226124.2
    Conserved Domains (2) summary
    smart00105
    Location:13 → 116
    ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
    pfam09507
    Location:134 → 291
    CDC27; DNA polymerase subunit Cdc27

  3. NM_025445.4 → NP_079721.2  ADP-ribosylation factor GTPase-activating protein 3 isoform 3

    See identical proteins and their annotated locations for NP_079721.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AC165945
    Consensus CDS
    CCDS49683.1
    UniProtKB/TrEMBL
    A0A0R4J0T8
    Related
    ENSMUSP00000064893.8, ENSMUST00000067215.9
    Conserved Domains (2) summary
    PLN03114
    Location:1 → 241
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    pfam01412
    Location:11 → 121
    ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83183940..83234576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521254.4 → XP_006521317.2  ADP-ribosylation factor GTPase-activating protein 3 isoform X1

    Conserved Domains (2) summary
    PLN03114
    Location:1 → 242
    PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional
    cd09028
    Location:4 → 123
    ArfGap_ArfGap3; Arf1 GTPase-activating protein 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8S3.2 GenPept UniProtKB/Swiss-Prot:Q9D8S3

Gene LinkOut

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