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Psmg3 proteasome (prosome, macropain) assembly chaperone 3 [ Mus musculus (house mouse) ]

Gene ID: 66506, updated on 18-Sep-2024

Summary

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Official Symbol
Psmg3provided by MGI
Official Full Name
proteasome (prosome, macropain) assembly chaperone 3provided by MGI
Primary source
MGI:MGI:1913756
See related
Ensembl:ENSMUSG00000029551 AllianceGenome:MGI:1913756
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810042K04Rik; 4930403H09Rik
Summary
Predicted to enable molecular adaptor activity. Predicted to be involved in chaperone-mediated protein complex assembly. Part of protein-containing complex. Orthologous to human PSMG3 (proteasome assembly chaperone 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 18.5), large intestine adult (RPKM 17.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Psmg3 in Genome Data Viewer
Location:
5 G2; 5 78.81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139809368..139812649, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139823613..139826894, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4803 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:140268130-140268313 Neighboring gene STARR-seq mESC enhancer starr_14698 Neighboring gene v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian) Neighboring gene transmembrane protein 184a Neighboring gene predicted gene, 38727 Neighboring gene leucine rich repeat and fibronectin type III, extracellular 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. 20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals. Le Tallec B, et al. Mol Cell, 2007 Aug 17. PMID 17707236
  2. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in chaperone-mediated protein complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proteasome assembly chaperone 3
Names
PAC-3
mPAC3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356963.1 → NP_001343892.1  proteasome assembly chaperone 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BE848654, CB203764
    Consensus CDS
    CCDS19815.1
    UniProtKB/Swiss-Prot
    Q9CZH3
    Related
    ENSMUSP00000138161.2, ENSMUST00000182602.2
    Conserved Domains (1) summary
    pfam10178
    Location:34 → 117
    PAC3; Proteasome assembly chaperone 3

  2. NM_025604.4 → NP_079880.1  proteasome assembly chaperone 3

    See identical proteins and their annotated locations for NP_079880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK012616, BE848654
    Consensus CDS
    CCDS19815.1
    UniProtKB/Swiss-Prot
    Q9CZH3
    Related
    ENSMUSP00000031531.7, ENSMUST00000031531.14
    Conserved Domains (1) summary
    pfam10178
    Location:34 → 117
    PAC3; Proteasome assembly chaperone 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139809368..139812649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZH3.1 GenPept UniProtKB/Swiss-Prot:Q9CZH3

Gene LinkOut

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