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Tnik TRAF2 and NCK interacting kinase [ Mus musculus (house mouse) ]

Gene ID: 665113, updated on 28-Oct-2024

Summary

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Official Symbol
Tnikprovided by MGI
Official Full Name
TRAF2 and NCK interacting kinaseprovided by MGI
Primary source
MGI:MGI:1916264
See related
Ensembl:ENSMUSG00000027692 AllianceGenome:MGI:1916264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1500031A17Rik; 4831440I19Rik; C530008O15Rik; C630040K21Rik
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 54. Orthologous to human TNIK (TRAF2 and NCK interacting kinase). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in frontal lobe adult (RPKM 7.4), cortex adult (RPKM 5.7) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Tnik in Genome Data Viewer
Location:
3 A3; 3 11.92 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (28317362..28724734)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (28261901..28670585)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07254 Neighboring gene phospholipase D1 Neighboring gene STARR-seq mESC enhancer starr_07256 Neighboring gene STARR-seq mESC enhancer starr_07258 Neighboring gene STARR-seq mESC enhancer starr_07259 Neighboring gene predicted gene, 42196 Neighboring gene predicted gene, 54170 Neighboring gene STARR-seq mESC enhancer starr_07260 Neighboring gene microRNA 466q Neighboring gene VISTA enhancer mm492 Neighboring gene STARR-seq mESC enhancer starr_07263 Neighboring gene STARR-seq mESC enhancer starr_07264 Neighboring gene STARR-seq mESC enhancer starr_07265 Neighboring gene RIKEN cDNA 1700112D23 gene Neighboring gene predicted gene, 52603 Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 2 Neighboring gene predicted pseudogene 6505

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice. Buchl SC, et al. Hepatol Commun, 2022 Mar. PMID 34677004, Free PMC Article
  2. Organization of TNIK in dendritic spines. Burette AC, et al. J Comp Neurol, 2015 Sep 1. PMID 25753355, Free PMC Article
  3. TNIK is a conserved regulator of glucose and lipid metabolism in obesity. Pham TCP, et al. Sci Adv, 2023 Aug 9. PMID 37556547, Free PMC Article
  4. Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK. Walczyk-Mooradally A, et al. J Neurochem, 2021 Sep. PMID 34077555, Free PMC Article
  5. TNIK signaling imprints CD8(+) T cell memory formation early after priming. Jaeger-Ruckstuhl CA, et al. Nat Commun, 2020 Apr 2. PMID 32242021, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNIK is a conserved regulator of glucose and lipid metabolism in obesity.
    Title: TNIK is a conserved regulator of glucose and lipid metabolism in obesity.
  2. Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice.
    Title: Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice.
  3. Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.
    Title: Phosphorylation-dependent control of Activity-regulated cytoskeleton-associated protein (Arc) protein by TNIK.
  4. TNIK is an important regulator of effector and memory T cell differentiation and induces a population of stem cell-like memory T cells.
    Title: TNIK signaling imprints CD8(+) T cell memory formation early after priming.
  5. TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach.
    Title: TNIK inhibition abrogates colorectal cancer stemness.
  6. This study demonstrate here that TNIK is expressed in neurons throughout the adult mouse brain.
    Title: Organization of TNIK in dendritic spines.
  7. TNiK is required for dentate gyrus neurogenesis & for pattern separation in a 2-choice spatial discrimination task & for glutamate-dependent object-location paired associate learning.
    Title: TNiK is required for postsynaptic and nuclear signaling pathways and cognitive function.
  8. TNIK maintains levels of glutamate receptors and other key postsynaptic density (PSD) proteins at the synapse, with loss of TNIK protein or inhibition of TNIK activity causing rapid degradation of PSD constituents.
    Title: The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.
  9. siRNA depletion of TNIK followed by expression array analysis showed that TNIK is an essential, specific activator of Wnt transcriptional programme.
    Title: The kinase TNIK is an essential activator of Wnt target genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0551, MGC189819, MGC189859

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendrite morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
traf2 and NCK-interacting protein kinase
NP_001156479.1
NP_001156480.1
NP_001156481.1
NP_081186.1
XP_006535580.1
XP_006535581.1
XP_006535582.1
XP_006535583.1
XP_006535584.1
XP_011248006.1
XP_011248007.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163007.1 → NP_001156479.1  traf2 and NCK-interacting protein kinase isoform 2

    See identical proteins and their annotated locations for NP_001156479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal, in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an 8 aa protein segment compared to isoform 1.
    Source sequence(s)
    BC050868, CK620825
    Consensus CDS
    CCDS50878.1
    UniProtKB/TrEMBL
    B2RXX2, B9EKN8
    Related
    ENSMUSP00000124876.3, ENSMUST00000159680.9
    Conserved Domains (2) summary
    smart00036
    Location:1034 → 1332
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  2. NM_001163008.1 → NP_001156480.1  traf2 and NCK-interacting protein kinase isoform 3

    See identical proteins and their annotated locations for NP_001156480.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two internal, in-frame coding exons compared to variant 1, resulting in a shorter isoform (3) missing two protein segments compared to isoform 1.
    Source sequence(s)
    BC050868
    Consensus CDS
    CCDS50879.1
    UniProtKB/Swiss-Prot
    P83510
    UniProtKB/TrEMBL
    B2RXX2
    Related
    ENSMUSP00000124681.3, ENSMUST00000159236.9
    Conserved Domains (3) summary
    smart00036
    Location:1005 → 1303
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  3. NM_001163009.1 → NP_001156481.1  traf2 and NCK-interacting protein kinase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal, in-frame coding exon, and differs at the 3' end compared to variant 1, resulting in a longer isoform (4) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC121268, AI115107, BC050868, CF531435, CK620825
    UniProtKB/TrEMBL
    B2RY17
    Related
    ENSMUST00000162037.9
    Conserved Domains (3) summary
    smart00036
    Location:1034 → 1326
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  4. NM_026910.1 → NP_081186.1  traf2 and NCK-interacting protein kinase isoform 1

    See identical proteins and their annotated locations for NP_081186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    BC050868, CD348964, CK620825
    Consensus CDS
    CCDS50877.1
    UniProtKB/TrEMBL
    B2RQ80, B2RXX2
    Related
    ENSMUSP00000125081.3, ENSMUST00000160307.9
    Conserved Domains (3) summary
    smart00036
    Location:1042 → 1340
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    28317362..28724734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535519.4 → XP_006535582.1  traf2 and NCK-interacting protein kinase isoform X3

    UniProtKB/TrEMBL
    B2RXX2
    Conserved Domains (2) summary
    smart00036
    Location:1045 → 1343
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  2. XM_006535517.4 → XP_006535580.1  traf2 and NCK-interacting protein kinase isoform X1

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:1045 → 1337
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  3. XM_006535518.4 → XP_006535581.1  traf2 and NCK-interacting protein kinase isoform X2

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:1042 → 1334
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  4. XM_006535521.4 → XP_006535584.1  traf2 and NCK-interacting protein kinase isoform X5

    UniProtKB/TrEMBL
    B2RXX2, E9PUL9
    Related
    ENSMUSP00000124011.2, ENSMUST00000160518.8
    Conserved Domains (2) summary
    smart00036
    Location:1013 → 1311
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  5. XM_006535520.4 → XP_006535583.1  traf2 and NCK-interacting protein kinase isoform X4

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:1016 → 1308
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cd06637
    Location:18 → 313
    STKc_TNIK; Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase

  6. XM_011249704.4 → XP_011248006.1  traf2 and NCK-interacting protein kinase isoform X6

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:990 → 1282
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 258
    PKc_like; Protein Kinases, catalytic domain

  7. XM_011249705.4 → XP_011248007.1  traf2 and NCK-interacting protein kinase isoform X7

    UniProtKB/TrEMBL
    B2RY17
    Conserved Domains (2) summary
    smart00036
    Location:961 → 1253
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:1 → 258
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_004941378.1 RNA Sequence

    Related
    ENSMUST00000160934.8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83510.2 GenPept UniProtKB/Swiss-Prot:P83510

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