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Vps28 vacuolar protein sorting 28 [ Mus musculus (house mouse) ]

Gene ID: 66914, updated on 5-Mar-2024

Summary

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Official Symbol
Vps28provided by MGI
Official Full Name
vacuolar protein sorting 28provided by MGI
Primary source
MGI:MGI:1914164
See related
Ensembl:ENSMUSG00000115987 AllianceGenome:MGI:1914164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIIA; 1110014J03Rik; D730005C08Rik
Summary
This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Expression
Ubiquitous expression in large intestine adult (RPKM 132.5), duodenum adult (RPKM 102.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Vps28 in Genome Data Viewer
Location:
15 D3; 15 36.17 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76506286..76510284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76622086..76626084, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene aarF domain containing kinase 5 Neighboring gene cleavage and polyadenylation specific factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1480 Neighboring gene STARR-seq mESC enhancer starr_39057 Neighboring gene solute carrier family 39 (zinc transporter), member 4 Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene zinc finger TRAF type containing 1 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1. Hwang HS, et al. J Cell Biol, 2011 Oct 31. PMID 22042618, Free PMC Article
  2. Identification of a novel antiapoptotic protein that antagonizes ASK1 and CAD activities. Cho SG, et al. J Cell Biol, 2003 Oct 13. PMID 14557248, Free PMC Article
  3. CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation. Hwang SG, et al. Mol Cell Biochem, 2014 Dec. PMID 25098452
  4. Protein-protein interaction panel using mouse full-length cDNAs. Suzuki H, et al. Genome Res, 2001 Oct. PMID 11591653, Free PMC Article
  5. An Interaction Landscape of Ubiquitin Signaling. Zhang X, et al. Mol Cell, 2017 Mar 2. PMID 28190767

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CIIA attenuates neurotoxicity caused by OGD/R through inhibiting ASK1-dependent signaling events.
    Title: CIIA negatively regulates neuronal cell death induced by oxygen-glucose deprivation and reoxygenation.
  2. CIIA functions as a molecular switch for the GEF activity of SOS1, directing this activity toward Rac1.
    Title: CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endosome transport via multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
vacuolar protein sorting-associated protein 28 homolog
Names
ESCRT-I complex subunit VPS28
caspase-activated DNase inhibitor that interacts with ASK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001305668.1 → NP_001292597.1  vacuolar protein sorting-associated protein 28 homolog isoform 2

    See identical proteins and their annotated locations for NP_001292597.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC157566, AK003572, AK003699, BY083019
    Consensus CDS
    CCDS88789.1
    UniProtKB/TrEMBL
    A0A2R8VKS6, Q8BMZ7
    Related
    ENSMUSP00000155847.2, ENSMUST00000229019.2
    Conserved Domains (1) summary
    pfam03997
    Location:1 → 181
    VPS28; VPS28 protein

  2. NM_025842.4 → NP_080118.1  vacuolar protein sorting-associated protein 28 homolog isoform 1

    See identical proteins and their annotated locations for NP_080118.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC157566, AK003699, AK013852, BY083019
    Consensus CDS
    CCDS27579.1
    UniProtKB/Swiss-Prot
    Q9D1C8
    UniProtKB/TrEMBL
    Q8BMZ7
    Related
    ENSMUSP00000077856.4, ENSMUST00000078803.5
    Conserved Domains (1) summary
    pfam03997
    Location:39 → 219
    VPS28; VPS28 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76506286..76510284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D1C8.1 GenPept UniProtKB/Swiss-Prot:Q9D1C8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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