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Thap4 THAP domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 67026, updated on 9-Dec-2024

Summary

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Official Symbol
Thap4provided by MGI
Official Full Name
THAP domain containing 4provided by MGI
Primary source
MGI:MGI:1914276
See related
Ensembl:ENSMUSG00000026279 AllianceGenome:MGI:1914276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nb(III); 2010320B01Rik
Summary
Predicted to enable several functions, including heme binding activity; nitric oxide binding activity; and peroxynitrite isomerase activity. Predicted to be involved in nitrate metabolic process and tyrosine metabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina nuclear layer; and submandibular gland primordium. Orthologous to human THAP4 (THAP domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in testis adult (RPKM 55.8), kidney adult (RPKM 23.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Thap4 in Genome Data Viewer
Location:
1 D; 1 47.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93633113..93682560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93705391..93754838, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene FERM, RhoGEF and pleckstrin domain protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95532366-95532549 Neighboring gene serine/threonine kinase 25 (yeast) Neighboring gene BCL2-related ovarian killer Neighboring gene STARR-seq mESC enhancer starr_01735 Neighboring gene autophagy related 4B, cysteine peptidase Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95698432-95698719 Neighboring gene deoxythymidylate kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice. Katayama K, et al. Mamm Genome, 2024 Jun. PMID 38658415
  2. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
    Title: Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitric oxide binding ISO
Inferred from Sequence Orthology
more info
  
enables nitric oxide binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables peroxynitrite isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables peroxynitrite isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in nitrate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in nitrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tyrosine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tyrosine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxynitrite isomerase THAP4
Names
THAP domain-containing protein 4
ferric nitrobindin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310761.1 → NP_001297690.1  peroxynitrite isomerase THAP4 isoform 2

    See identical proteins and their annotated locations for NP_001297690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons and contains an alternate 5' exon compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC131316, AK167814, BE863103
    Consensus CDS
    CCDS78657.1
    UniProtKB/TrEMBL
    A0A0J9YU08
    Related
    ENSMUSP00000143943.2, ENSMUST00000189728.7
    Conserved Domains (1) summary
    cd07828
    Location:10 → 162
    nitrobindin; nitrobindin heme-binding domain

  2. NM_025920.3 → NP_080196.3  peroxynitrite isomerase THAP4 isoform 1

    See identical proteins and their annotated locations for NP_080196.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK167814, BC066042
    Consensus CDS
    CCDS15194.1
    UniProtKB/Swiss-Prot
    Q3US28, Q6NZN6, Q6P3Z3, Q6PEN6, Q91WR2, Q9CVE5, Q9CVG3
    Related
    ENSMUSP00000140761.2, ENSMUST00000190116.7
    Conserved Domains (4) summary
    smart00980
    Location:4 → 85
    THAP; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion
    PHA03307
    Location:123 → 314
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam09486
    Location:342 → 389
    HrpB7; Bacterial type III secretion protein (HrpB7)
    cd07828
    Location:414 → 567
    lipocalin_heme-bd-THAP4-like; heme-binding beta-barrel domain of human THAP4, Arabidopsis thaliana nitrobindin, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    93633113..93682560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P3Z3.1 GenPept UniProtKB/Swiss-Prot:Q6P3Z3

Gene LinkOut

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