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Ccdc77 coiled-coil domain containing 77 [ Mus musculus (house mouse) ]

Gene ID: 67200, updated on 9-Dec-2024

Summary

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Official Symbol
Ccdc77provided by MGI
Official Full Name
coiled-coil domain containing 77provided by MGI
Primary source
MGI:MGI:1914450
See related
Ensembl:ENSMUSG00000030177 AllianceGenome:MGI:1914450
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2400002C23Rik; 2700091N06Rik
Summary
Predicted to be active in centrosome. Orthologous to human CCDC77 (coiled-coil domain containing 77). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in CNS E11.5 (RPKM 4.9), liver E14 (RPKM 4.4) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Ccdc77 in Genome Data Viewer
Location:
6 F1; 6 56.95 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (120301283..120341330, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (120324322..120364369, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ninjurin 2 Neighboring gene STARR-positive B cell enhancer ABC_E2801 Neighboring gene STARR-positive B cell enhancer ABC_E2802 Neighboring gene predicted gene, 25327 Neighboring gene STARR-positive B cell enhancer ABC_E10405 Neighboring gene STARR-seq mESC enhancer starr_17164 Neighboring gene STARR-positive B cell enhancer ABC_E6477 Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 3 Neighboring gene STARR-seq mESC enhancer starr_17178 Neighboring gene STARR-seq mESC enhancer starr_17179 Neighboring gene STARR-seq mESC enhancer starr_17181 Neighboring gene STARR-positive B cell enhancer ABC_E3675 Neighboring gene STARR-positive B cell enhancer ABC_E11334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120314296-120314483 Neighboring gene lysine demethylase 5A Neighboring gene predicted gene, 24592 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:120416743-120416991 Neighboring gene STARR-positive B cell enhancer ABC_E685 Neighboring gene STARR-positive B cell enhancer ABC_E10406 Neighboring gene interleukin 17 receptor A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Hein MY, et al. Cell, 2015 Oct 22. PMID 26496610

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 77

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001381934.1 → NP_001368863.1  coiled-coil domain-containing protein 77 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155720
    UniProtKB/Swiss-Prot
    Q8VEJ7, Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:46 → 377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001381935.1 → NP_001368864.1  coiled-coil domain-containing protein 77 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155720
    Conserved Domains (1) summary
    TIGR02168
    Location:28 → 359
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_001381936.1 → NP_001368865.1  coiled-coil domain-containing protein 77 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC155720
    Related
    ENSMUSP00000108323.2, ENSMUST00000112703.8
    Conserved Domains (1) summary
    TIGR02168
    Location:28 → 359
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. NM_001381937.1 → NP_001368866.1  coiled-coil domain-containing protein 77 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155720
    Conserved Domains (1) summary
    pfam15921
    Location:28 → 434
    CCDC158; Coiled-coil domain-containing protein 158

  5. NM_001381938.1 → NP_001368867.1  coiled-coil domain-containing protein 77 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC155720
    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 268
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. NM_026028.5 → NP_080304.1  coiled-coil domain-containing protein 77 isoform 1

    See identical proteins and their annotated locations for NP_080304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AK012598, AK031590, BU757887, CD555913
    Consensus CDS
    CCDS20481.1
    UniProtKB/Swiss-Prot
    Q8VEJ7, Q9CZH8
    Related
    ENSMUSP00000032283.6, ENSMUST00000032283.12
    Conserved Domains (1) summary
    TIGR02168
    Location:46 → 377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. NR_045558.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) difers in the 5' UTR and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK031590, BU757887, CX205399
    Related
    ENSMUST00000127146.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    120301283..120341330 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506495.3 → XP_006506558.1  coiled-coil domain-containing protein 77 isoform X2

    See identical proteins and their annotated locations for XP_006506558.1

    UniProtKB/Swiss-Prot
    Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:28 → 359
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006506490.4 → XP_006506553.1  coiled-coil domain-containing protein 77 isoform X1

    See identical proteins and their annotated locations for XP_006506553.1

    UniProtKB/Swiss-Prot
    Q8VEJ7, Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:46 → 377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. XM_006506494.4 → XP_006506557.1  coiled-coil domain-containing protein 77 isoform X2

    See identical proteins and their annotated locations for XP_006506557.1

    UniProtKB/Swiss-Prot
    Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:28 → 359
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006506491.5 → XP_006506554.1  coiled-coil domain-containing protein 77 isoform X1

    See identical proteins and their annotated locations for XP_006506554.1

    UniProtKB/Swiss-Prot
    Q8VEJ7, Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:46 → 377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_006506500.5 → XP_006506563.1  coiled-coil domain-containing protein 77 isoform X4

    Conserved Domains (1) summary
    TIGR02168
    Location:54 → 405
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  6. XM_006506499.4 → XP_006506562.1  coiled-coil domain-containing protein 77 isoform X3

    See identical proteins and their annotated locations for XP_006506562.1

    Conserved Domains (1) summary
    TIGR02168
    Location:52 → 355
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  7. XM_011241435.3 → XP_011239737.1  coiled-coil domain-containing protein 77 isoform X3

    See identical proteins and their annotated locations for XP_011239737.1

    Conserved Domains (1) summary
    TIGR02168
    Location:52 → 355
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  8. XM_011241439.4 → XP_011239741.1  coiled-coil domain-containing protein 77 isoform X5

    See identical proteins and their annotated locations for XP_011239741.1

    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 268
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  9. XM_011241432.4 → XP_011239734.1  coiled-coil domain-containing protein 77 isoform X1

    See identical proteins and their annotated locations for XP_011239734.1

    UniProtKB/Swiss-Prot
    Q8VEJ7, Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:46 → 377
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  10. XM_011241433.4 → XP_011239735.1  coiled-coil domain-containing protein 77 isoform X2

    See identical proteins and their annotated locations for XP_011239735.1

    UniProtKB/Swiss-Prot
    Q9CZH8
    Conserved Domains (1) summary
    TIGR02168
    Location:28 → 359
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  11. XM_036152269.1 → XP_036008162.1  coiled-coil domain-containing protein 77 isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:2 → 268
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_011241434.1 → XP_011239736.1  coiled-coil domain-containing protein 77 isoform X3

    See identical proteins and their annotated locations for XP_011239736.1

    Conserved Domains (1) summary
    TIGR02168
    Location:52 → 355
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_004933618.1 RNA Sequence

  2. XR_001785160.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZH8.1 GenPept UniProtKB/Swiss-Prot:Q9CZH8

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