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Lsm1 LSM1 homolog, mRNA degradation associated [ Mus musculus (house mouse) ]

Gene ID: 67207, updated on 9-Dec-2024

Summary

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Official Symbol
Lsm1provided by MGI
Official Full Name
LSM1 homolog, mRNA degradation associatedprovided by MGI
Primary source
MGI:MGI:1914457
See related
Ensembl:ENSMUSG00000037296 AllianceGenome:MGI:1914457
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CASM; 2810025O06Rik
Summary
Predicted to enable mRNA binding activity and pre-mRNA binding activity. Acts upstream of or within negative regulation of neuron differentiation and stem cell population maintenance. Located in P-body. Is expressed in central nervous system; heart; metanephros; and submandibular gland. Orthologous to human LSM1 (LSM1 homolog, mRNA degradation associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.5), CNS E11.5 (RPKM 6.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lsm1 in Genome Data Viewer
Location:
8 A2; 8 14.17 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26275326..26294003)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25785318..25803975)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17484 Neighboring gene BCL2-associated athanogene 4 Neighboring gene electron transferring flavoprotein, alpha polypeptide pseudogene Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene Star 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_20984 Neighboring gene steroidogenic acute regulatory protein Neighboring gene ASH2 like histone lysine methyltransferase complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E9309

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eri1 degrades the stem-loop of oligouridylated histone mRNAs to induce replication-dependent decay. Hoefig KP, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23202588
  2. Analysis of cDNA sequences from mouse testis. Kerr SM, et al. Mamm Genome, 1994 Sep. PMID 8000140
  3. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Yang G, et al. Neuron, 2014 Nov 19. PMID 25456498
  4. Minor spliceosome components are predominantly localized in the nucleus. Pessa HK, et al. Proc Natl Acad Sci U S A, 2008 Jun 24. PMID 18559850, Free PMC Article
  5. TRIM24 is an insulin-responsive regulator of P-bodies. Wei W, et al. Nat Commun, 2022 Jul 8. PMID 35803934, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in histone mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
U6 snRNA-associated Sm-like protein LSm1
Names
LSM1 homolog, U6 small nuclear RNA associated
U6 small nuclear RNA associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026032.1 → NP_080308.1  U6 snRNA-associated Sm-like protein LSm1

    See identical proteins and their annotated locations for NP_080308.1

    Status: VALIDATED

    Source sequence(s)
    AK041290
    Consensus CDS
    CCDS22202.1
    UniProtKB/Swiss-Prot
    Q8VC85
    UniProtKB/TrEMBL
    Q544C9
    Related
    ENSMUSP00000041022.7, ENSMUST00000038421.8
    Conserved Domains (2) summary
    PRK10788
    Location:64 → 131
    PRK10788; periplasmic folding chaperone; Provisional
    cd01728
    Location:4 → 77
    LSm1; Like-Sm protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26275326..26294003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242156.4 → XP_011240458.1  U6 snRNA-associated Sm-like protein LSm1 isoform X1

    Conserved Domains (1) summary
    cd01728
    Location:4 → 77
    LSm1; Like-Sm protein 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VC85.1 GenPept UniProtKB/Swiss-Prot:Q8VC85

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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