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Zkscan14 zinc finger with KRAB and SCAN domains 14 [ Mus musculus (house mouse) ]

Gene ID: 67235, updated on 17-Aug-2024

Summary

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Official Symbol
Zkscan14provided by MGI
Official Full Name
zinc finger with KRAB and SCAN domains 14provided by MGI
Primary source
MGI:MGI:1914485
See related
Ensembl:ENSMUSG00000029627 AllianceGenome:MGI:1914485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp99; Znf394; 2310046C23Rik; 2810437E14Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in early conceptus and genitourinary system. Orthologous to human ZNF394 (zinc finger protein 394). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 2.2), cerebellum adult (RPKM 2.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 85.12 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145131756..145140972, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145194946..145204164, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6397 Neighboring gene cleavage and polyadenylation specific factor 4 Neighboring gene ATP synthase membrane subunit f Neighboring gene STARR-positive B cell enhancer ABC_E1316 Neighboring gene STARR-positive B cell enhancer ABC_E533 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene zinc finger protein 655

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia. Dickerson KM, et al. Blood Cancer Discov, 2022 May 5. PMID 35247902, Free PMC Article
  2. Three novel spermatogenesis-specific zinc finger genes. Weissig H, et al. FEBS Lett, 2003 Jul 17. PMID 12860387
  3. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  4. Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders. Li J, et al. Nat Neurosci, 2017 Aug. PMID 28671696, Free PMC Article
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
    Title: ZNF384 Fusion Oncoproteins Drive Lineage Aberrancy in Acute Leukemia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117641

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 394
Names
zfp-94
zinc finger protein 94
zinc finger protein 99
zinc finger protein with KRAB and SCAN domains 14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023322.2 → NP_075811.2  zinc finger protein 394

    See identical proteins and their annotated locations for NP_075811.2

    Status: VALIDATED

    Source sequence(s)
    AI195146, AK013258, CJ072232
    Consensus CDS
    CCDS19860.1
    UniProtKB/Swiss-Prot
    B9EIZ4, Q3U4Z1, Q9CYV9, Q9CZG8, Q9Z1D9
    Related
    ENSMUSP00000031632.9, ENSMUST00000031632.9
    Conserved Domains (8) summary
    smart00431
    Location:40 → 151
    SCAN; leucine rich region
    cd07765
    Location:135 → 173
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:135 → 193
    KRAB; krueppel associated box
    COG5048
    Location:303 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:329 → 349
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:438 → 460
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:40 → 128
    SCAN; SCAN domain
    pfam13465
    Location:341 → 366
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145131756..145140972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241012.4 → XP_011239314.1  zinc finger protein 394 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:1 → 59
    KRAB; krueppel associated box
    COG5048
    Location:169 → 350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:195 → 215
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:347 → 371
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1D9.3 GenPept UniProtKB/Swiss-Prot:Q9Z1D9

Gene LinkOut

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