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Washc3 WASH complex subunit 3 [ Mus musculus (house mouse) ]

Gene ID: 67282, updated on 9-Dec-2024

Summary

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Official Symbol
Washc3provided by MGI
Official Full Name
WASH complex subunit 3provided by MGI
Primary source
MGI:MGI:1914532
See related
Ensembl:ENSMUSG00000020056 AllianceGenome:MGI:1914532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc53; 2900091E11Rik; 5730495F03Rik
Summary
Predicted to be involved in actin filament polymerization and exocytosis. Part of WASH complex. Is expressed in several structures, including adipose tissue; central nervous system; eye; liver; and thymus primordium. Orthologous to human WASHC3 (WASH complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 9.0), bladder adult (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Washc3 in Genome Data Viewer
Location:
10 C1; 10 43.7 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88036954..88160001)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88201097..88324139)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene PARP1 binding protein Neighboring gene predicted gene 6653 Neighboring gene nucleoporin 37 Neighboring gene STARR-seq mESC enhancer starr_27492 Neighboring gene predicted gene, 26357 Neighboring gene STARR-positive B cell enhancer ABC_E6896 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:87666206-87666315 Neighboring gene predicted gene 8415 Neighboring gene WD repeat domain 75 pseudogene Neighboring gene DNA-damage regulated autophagy modulator 1 Neighboring gene predicted gene, 51779 Neighboring gene STARR-positive B cell enhancer ABC_E2332 Neighboring gene predicted gene, 40733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A FAM21-containing WASH complex regulates retromer-dependent sorting. Gomez TS, et al. Dev Cell, 2009 Nov. PMID 19922874, Free PMC Article
  2. Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour. Tyrrell BJ, et al. Pigment Cell Melanoma Res, 2016 Sep. PMID 27390154, Free PMC Article
  3. The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. Derivery E, et al. Dev Cell, 2009 Nov. PMID 19922875
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Arp2/3 complex-mediated actin nucleation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of WASH complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of WASH complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of WASH complex ISO
Inferred from Sequence Orthology
more info
  
part_of WASH complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of WASH complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in early endosome membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
WASH complex subunit 3
Names
WASH complex subunit CCDC53
coiled-coil domain containing 53
coiled-coil domain-containing protein 53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122960.2 → NP_001116432.1  WASH complex subunit 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC168315
    Consensus CDS
    CCDS59550.1
    UniProtKB/TrEMBL
    S4R287
    Related
    ENSMUSP00000138540.2, ENSMUST00000182183.8
    Conserved Domains (1) summary
    pfam10152
    Location:30 → 166
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)

  2. NM_001429467.1 → NP_001416396.1  WASH complex subunit 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC168315
    UniProtKB/TrEMBL
    S4R1P7

  3. NM_026070.4 → NP_080346.1  WASH complex subunit 3 isoform 1

    See identical proteins and their annotated locations for NP_080346.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC168315
    Consensus CDS
    CCDS24108.1
    UniProtKB/Swiss-Prot
    Q8K2X5, Q9CR27, Q9D0Y7
    Related
    ENSMUSP00000020248.9, ENSMUST00000020248.16
    Conserved Domains (1) summary
    pfam10152
    Location:30 → 167
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)

  4. NM_027487.2 → NP_081763.1  WASH complex subunit 3 isoform 3

    See identical proteins and their annotated locations for NP_081763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon that creates a unique 3' coding region and 3' UTR, compared to variant 1, resulting in a shorter protein (isoform 3) with a novel C-terminus, compared to isoform 1.
    Source sequence(s)
    AC168315
    Consensus CDS
    CCDS48664.1
    UniProtKB/TrEMBL
    G3UWG7, S4R1P7
    Related
    ENSMUSP00000132246.2, ENSMUST00000171151.9
    Conserved Domains (1) summary
    pfam10152
    Location:30 → 145
    DUF2360; Predicted coiled-coil domain-containing protein (DUF2360)

RNA

  1. NR_190735.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC168315

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    88036954..88160001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245232.1 → XP_030101092.1  WASH complex subunit 3 isoform X1

    Related
    ENSMUSP00000138310.2, ENSMUST00000182619.2
    Conserved Domains (1) summary
    pfam10152
    Location:30 → 144
    CCDC53; Subunit CCDC53 of WASH complex

RNA

  1. XR_003948780.2 RNA Sequence

  2. XR_003948781.2 RNA Sequence

  3. XR_004936257.1 RNA Sequence

  4. XR_003948777.2 RNA Sequence

  5. XR_004936258.1 RNA Sequence

  6. XR_003948779.2 RNA Sequence

  7. XR_003948783.2 RNA Sequence

  8. XR_004936259.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR27.1 GenPept UniProtKB/Swiss-Prot:Q9CR27

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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