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Prl8a9 prolactin family8, subfamily a, member 9 [ Mus musculus (house mouse) ]

Gene ID: 67310, updated on 9-Aug-2024

Summary

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Official Symbol
Prl8a9provided by MGI
Official Full Name
prolactin family8, subfamily a, member 9provided by MGI
Primary source
MGI:MGI:1914560
See related
Ensembl:ENSMUSG00000006490 AllianceGenome:MGI:1914560
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ghd15; PLP-C2; Prlpc2; PLP-Cbeta; 1600019F10Rik
Summary
Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including positive regulation of lactation; positive regulation of pri-miRNA transcription by RNA polymerase II; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including extraembryonic component and placenta. Human ortholog(s) of this gene implicated in carotid artery disease. Orthologous to human PRL (prolactin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward placenta adult (RPKM 810.0) See more
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Genomic context

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See Prl8a9 in Genome Data Viewer
Location:
13 A3.1; 13 12.52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (27741978..27748589, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (27557995..27564606, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40836 Neighboring gene prolactin family 8, subfamily a, member 6 Neighboring gene prolactin family 8, subfamily a, member 81 Neighboring gene STARR-seq mESC enhancer starr_34016 Neighboring gene prolactin family 8, subfamily a, member 1 Neighboring gene prolactin family 7, subfamily b, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of a new member of the placental prolactin-like protein-C (PLP-C) subfamily, PLP-Cbeta. Hwang IT, et al. Endocrinology, 2000 Sep. PMID 10965907
  2. Bridging sequence diversity and tissue-specific expression by DNA methylation in genes of the mouse prolactin superfamily. Hayakawa K, et al. Mamm Genome, 2012 Jun. PMID 22193412, Free PMC Article
  3. The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources. Tunster SJ, et al. Dev Biol, 2016 Jan 1. PMID 26476147, Free PMC Article
  4. A standardized nomenclature for the mouse and rat prolactin superfamilies. Soares MJ, et al. Mamm Genome, 2007 Mar. PMID 17476555
  5. Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus. Simmons DG, et al. BMC Genomics, 2008 Jul 28. PMID 18662396, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables prolactin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in female pregnancy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mammary gland development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of lactation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to nutrient levels IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolactin-8A9
Names
PLP C-beta
PRL-like protein C2
growth hormone d15
placental prolactin-like protein C2
prolactin-like protein C 2
prolactin-like protein C-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316721.1 → NP_001303650.1  prolactin-8A9 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK005409, BU754779, BY035815
    UniProtKB/Swiss-Prot
    Q9CQ58
    Conserved Domains (1) summary
    cd10288
    Location:30 → 240
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

  2. NM_023332.4 → NP_075821.1  prolactin-8A9 isoform 1 precursor

    See identical proteins and their annotated locations for NP_075821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK005494, BU754779, BY035815
    Consensus CDS
    CCDS26400.1
    UniProtKB/Swiss-Prot
    Q9CQ58
    UniProtKB/TrEMBL
    A0A0M6L0N6
    Related
    ENSMUSP00000006662.3, ENSMUST00000006662.4
    Conserved Domains (1) summary
    cd10288
    Location:31 → 241
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    27741978..27748589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ58.1 GenPept UniProtKB/Swiss-Prot:Q9CQ58

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