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Kcnv1 potassium channel, subfamily V, member 1 [ Mus musculus (house mouse) ]

Gene ID: 67498, updated on 2-Nov-2024

Summary

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Official Symbol
Kcnv1provided by MGI
Official Full Name
potassium channel, subfamily V, member 1provided by MGI
Primary source
MGI:MGI:1914748
See related
Ensembl:ENSMUSG00000022342 AllianceGenome:MGI:1914748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
vibe; 2700023A03Rik
Summary
Predicted to enable potassium channel activity and potassium channel regulator activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Predicted to be located in intercellular bridge and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNV1 (potassium voltage-gated channel modifier subfamily V member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 3.4), frontal lobe adult (RPKM 2.6) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnv1 in Genome Data Viewer
Location:
15 B3.3; 15 17.25 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (44959482..44979375, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (45096086..45115912, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38579 Neighboring gene H3 histone, family 3B pseudogene Neighboring gene predicted pseudogene 5471 Neighboring gene STARR-seq mESC enhancer starr_38580 Neighboring gene STARR-seq mESC enhancer starr_38581 Neighboring gene STARR-seq mESC enhancer starr_38582 Neighboring gene predicted gene, 57628 Neighboring gene STARR-seq mESC enhancer starr_38583 Neighboring gene STARR-seq mESC enhancer starr_38585 Neighboring gene STARR-seq mESC enhancer starr_38586 Neighboring gene STARR-seq mESC enhancer starr_38587 Neighboring gene STARR-seq mESC enhancer starr_38588 Neighboring gene STARR-seq mESC enhancer starr_38589 Neighboring gene STARR-seq mESC enhancer starr_38590 Neighboring gene Kruppel-like factor 5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily V member 1
Names
neuronal potassium channel alpha subunit
potassium channel Kv8.1 homolog
voltage-gated potassium channel subunit Kv8.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026200.3 → NP_080476.2  potassium voltage-gated channel subfamily V member 1

    See identical proteins and their annotated locations for NP_080476.2

    Status: VALIDATED

    Source sequence(s)
    AK034091, AK139482, CJ151712
    Consensus CDS
    CCDS27459.1
    UniProtKB/Swiss-Prot
    Q8BK61, Q8BYS7, Q8BZN2, Q9CZR1
    Related
    ENSMUSP00000022967.6, ENSMUST00000022967.7
    Conserved Domains (2) summary
    cl38908
    Location:44 → 163
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:212 → 438
    Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    44959482..44979375 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521297.5 → XP_006521360.1  potassium voltage-gated channel subfamily V member 1 isoform X1

    See identical proteins and their annotated locations for XP_006521360.1

    UniProtKB/Swiss-Prot
    Q8BK61, Q8BYS7, Q8BZN2, Q9CZR1
    Conserved Domains (2) summary
    cl38908
    Location:44 → 163
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam00520
    Location:212 → 438
    Ion_trans; Ion transport protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZN2.2 GenPept UniProtKB/Swiss-Prot:Q8BZN2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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