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Cuta cutA divalent cation tolerance homolog [ Mus musculus (house mouse) ]

Gene ID: 67675, updated on 9-Dec-2024

Summary

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Official Symbol
Cutaprovided by MGI
Official Full Name
cutA divalent cation tolerance homologprovided by MGI
Primary source
MGI:MGI:1914925
See related
Ensembl:ENSMUSG00000024194 AllianceGenome:MGI:1914925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610039D01Rik; 1810022E02Rik; 1810060C03Rik; 2700094G22Rik
Summary
Predicted to enable copper ion binding activity and enzyme binding activity. Predicted to be involved in protein localization. Predicted to be located in membrane. Orthologous to human CUTA (cutA divalent cation tolerance homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 82.5), duodenum adult (RPKM 48.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cuta in Genome Data Viewer
Location:
17 A3.3; 17 13.6 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27156946..27158847, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26937972..26939884, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C5B Neighboring gene microRNA 6967-1 Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene PHD finger protein 1 Neighboring gene microRNA 6968 Neighboring gene synaptic Ras GTPase activating protein 1 homolog (rat) Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Unusual transfer of CutA into the secretory pathway, evidenced by fusion proteins with acetylcholinesterase. Liang D, et al. FEBS J, 2009 Aug. PMID 19645739
  2. Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation. Hou P, et al. Neurobiol Aging, 2015 Mar. PMID 25557959
  3. Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase. Liang D, et al. J Biol Chem, 2009 Feb 20. PMID 19049969
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an N-terminal CutA domain actually drives AChE into the endoplasmic reticulum and allows its secretion
    Title: Unusual transfer of CutA into the secretory pathway, evidenced by fusion proteins with acetylcholinesterase.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in response to metal ion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein CutA
Names
brain acetylcholinesterase putative membrane anchor
divalent cation tolerant protein CUTA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026307.3 → NP_080583.3  protein CutA isoform 1 precursor

    See identical proteins and their annotated locations for NP_080583.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AA197830, AK002828, CA323205
    Consensus CDS
    CCDS28557.1
    UniProtKB/Swiss-Prot
    Q3TXB6, Q8CI44, Q9CQ89, Q9D1L4
    Related
    ENSMUSP00000025027.9, ENSMUST00000025027.10
    Conserved Domains (1) summary
    pfam03091
    Location:70 → 164
    CutA1; CutA1 divalent ion tolerance protein

  2. NM_026948.3 → NP_081224.1  protein CutA isoform 2

    See identical proteins and their annotated locations for NP_081224.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, which results in a downstream AUG start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA197830, AK003381, CA323205
    Consensus CDS
    CCDS37519.1
    UniProtKB/TrEMBL
    D5MCW4
    Related
    ENSMUSP00000110585.2, ENSMUST00000114935.9
    Conserved Domains (1) summary
    pfam03091
    Location:47 → 141
    CutA1; CutA1 divalent ion tolerance protein

RNA

  1. NR_104458.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a splice junction in the 5' region and has an alternate splice site in the central region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK007912, BY033979, BY057392, CK624897
    Related
    ENSMUST00000236888.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27156946..27158847 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250013.2 → XP_030105873.1  protein CutA isoform X1

    Conserved Domains (1) summary
    pfam03091
    Location:167 → 226
    CutA1; CutA1 divalent ion tolerance protein

  2. XM_006524832.5 → XP_006524895.1  protein CutA isoform X2

    UniProtKB/TrEMBL
    A0A494BAZ9
    Conserved Domains (1) summary
    pfam03091
    Location:69 → 104
    CutA1; CutA1 divalent ion tolerance protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQ89.3 GenPept UniProtKB/Swiss-Prot:Q9CQ89

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