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Ost4 oligosaccharyltransferase complex subunit 4 (non-catalytic) [ Mus musculus (house mouse) ]

Gene ID: 67695, updated on 4-Jan-2025

Summary

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Official Symbol
Ost4provided by MGI
Official Full Name
oligosaccharyltransferase complex subunit 4 (non-catalytic)provided by MGI
Primary source
MGI:MGI:1914945
See related
Ensembl:ENSMUSG00000038803 AllianceGenome:MGI:1914945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310016E02Rik
Summary
Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to be part of oligosaccharyltransferase complex. Is expressed in Meckel's cartilage; cerebral cortex ventricular layer; and orbito-sphenoid. Orthologous to human OST4 (oligosaccharyltransferase complex subunit 4, non-catalytic). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in placenta adult (RPKM 157.9), genital fat pad adult (RPKM 151.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ost4 in Genome Data Viewer
Location:
5 B1; 5 16.9 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31063860..31065155, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30906516..30907807, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35795 Neighboring gene nuclear encoded tRNA alanine 15 (anticodon AGC) Neighboring gene nuclear encoded tRNA tyrosine 9 (anticodon GTA) Neighboring gene ATP/GTP binding protein-like 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31218364-31218473 Neighboring gene elastin microfibril interfacer 1 Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B. Ramírez AS, et al. Science, 2019 Dec 13. PMID 31831667
  2. Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line. Chu VT, et al. Proc Natl Acad Sci U S A, 2016 Nov 1. PMID 27729526, Free PMC Article
  3. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein N-linked glycosylation via asparagine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation via asparagine IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation via asparagine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex ISO
Inferred from Sequence Orthology
more info
  
part_of oligosaccharyltransferase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4
Names
oligosaccharyltransferase 4 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134692.2 → NP_001128164.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

    See identical proteins and their annotated locations for NP_001128164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC082316, BU756604, DV041491
    Consensus CDS
    CCDS39049.1
    UniProtKB/Swiss-Prot
    Q99LX8
    Related
    ENSMUSP00000126221.2, ENSMUST00000132034.5
    Conserved Domains (1) summary
    pfam10215
    Location:1 → 34
    Ost4; Oligosaccaryltransferase

  2. NM_024460.4 → NP_077780.3  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

    See identical proteins and their annotated locations for NP_077780.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK003569, BU756604, DV041491
    Consensus CDS
    CCDS39049.1
    UniProtKB/Swiss-Prot
    Q99LX8
    Related
    ENSMUSP00000128352.2, ENSMUST00000132253.5
    Conserved Domains (1) summary
    pfam10215
    Location:1 → 34
    Ost4; Oligosaccaryltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31063860..31065155 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504071.5 → XP_006504134.1  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 isoform X1

    See identical proteins and their annotated locations for XP_006504134.1

    UniProtKB/Swiss-Prot
    Q99LX8
    Conserved Domains (1) summary
    pfam10215
    Location:1 → 34
    Ost4; Oligosaccaryltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LX8.1 GenPept UniProtKB/Swiss-Prot:Q99LX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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