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ZFP36L2 ZFP36 ring finger protein like 2 [ Homo sapiens (human) ]

Gene ID: 678, updated on 2-Nov-2024

Summary

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Official Symbol
ZFP36L2provided by HGNC
Official Full Name
ZFP36 ring finger protein like 2provided by HGNC
Primary source
HGNC:HGNC:1108
See related
Ensembl:ENSG00000152518 MIM:612053; AllianceGenome:HGNC:1108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRF2; ERF2; ERF-2; OOMD13; TIS11D; OZEMA13; RNF162C
Summary
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 108.0), appendix (RPKM 94.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ZFP36L2 in Genome Data Viewer
Location:
2p21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (43222402..43226606, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (43227768..43231972, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (43449541..43453745, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15658 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43360411-43361174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43361175-43361936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43367134-43367705 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43367706-43368276 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:43379975-43380123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:43384913-43385431 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:43385646-43385841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:43394830-43395476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:43396769-43397414 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:43397590-43398275 Neighboring gene uncharacterized LOC124907755 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43404972-43405498 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1717 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43407075-43407600 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:43411165-43412364 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43412481-43413214 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43413949-43414682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43414683-43415416 Neighboring gene CRISPRi-validated cis-regulatory element chr2.1723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:43421149-43422068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43437212-43437806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:43441787-43442553 Neighboring gene VISTA enhancer hs1909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15664 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11423 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43453393-43454356 Neighboring gene long intergenic non-protein coding RNA 1126 Neighboring gene Sharpr-MPRA regulatory region 2712 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43500316-43500816 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43500817-43501317 Neighboring gene THADA armadillo repeat containing Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:43519973-43521172 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:43524271-43524772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15670 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15672 Neighboring gene RNA, U6 small nuclear 958, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. Iwanaga E, et al. Int J Oncol, 2011 Jan. PMID 21109922, Free PMC Article
  2. Genomic evolution and diverse models of systemic metastases in colorectal cancer. Chen HN, et al. Gut, 2022 Feb. PMID 33632712, Free PMC Article
  3. Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer. Xing R, et al. Nat Commun, 2019 May 2. PMID 31048690, Free PMC Article
  4. Probing the structural and dynamical effects of the charged residues of the TZF domain of TIS11d. Morgan BR, et al. Biophys J, 2015 Mar 24. PMID 25809263, Free PMC Article
  5. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Hudson BP, et al. Nat Struct Mol Biol, 2004 Mar. PMID 14981510

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
    Title: Genetic association and functional validation of ZFP36L2 in non-syndromic orofacial cleft subtypes.
  2. A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
    Title: A novel homozygous variant in ZFP36L2 cause female infertility due to oocyte maturation defect.
  3. TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.
    Title: TREC mediated oncogenesis in human immature T lymphoid malignancies preferentially involves ZFP36L2.
  4. The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
    Title: The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells.
  5. Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.
    Title: Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.
  6. Genomic evolution and diverse models of systemic metastases in colorectal cancer.
    Title: Genomic evolution and diverse models of systemic metastases in colorectal cancer.
  7. ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
    Title: ZFP36 Family Members Regulate the Proinflammatory Features of Psoriatic Dermal Fibroblasts.
  8. Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.
    Title: Silencing of ZFP36L2 increases sensitivity to temozolomide through G2/M cell cycle arrest and BAX mediated apoptosis in GBM cells.
  9. RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
    Title: RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
  10. The results indicated that ZFP36L1 and ZFP36L2 play a negative role in cell proliferation; the underlying mechanisms might be mediated through a cyclin D-dependent and p53-independent pathway.
    Title: ZFP36L1 and ZFP36L2 inhibit cell proliferation in a cyclin D-dependent and p53-independent manner.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Oocyte maturation defect 13
MedGen: C5774268 OMIM: 620154 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA 3'-UTR AU-rich region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-UTR-mediated mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in 3'-UTR-mediated mRNA destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in T cell differentiation in thymus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to epidermal growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to fibroblast growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in definitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of mitotic cell cycle phase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of stem cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to wounding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in somatic stem cell division ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in somatic stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mRNA decay activator protein ZFP36L2
Names
EGF-response factor 2
TPA-induced sequence 11d
ZFP36-like 2
butyrate response factor 2 (EGF-response factor 2)
zinc finger protein 36, C3H type-like 1
zinc finger protein 36, C3H type-like 2
zinc finger protein 36, C3H1 type-like 2
zinc finger protein, C3H type, 36-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006887.5 → NP_008818.3  mRNA decay activator protein ZFP36L2

    See identical proteins and their annotated locations for NP_008818.3

    Status: REVIEWED

    Source sequence(s)
    AC010883, N67537
    Consensus CDS
    CCDS1811.1
    UniProtKB/Swiss-Prot
    P47974, Q53TB4, Q9BSJ3
    Related
    ENSP00000282388.3, ENST00000282388.4
    Conserved Domains (2) summary
    pfam00642
    Location:154 → 179
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam04553
    Location:3 → 131
    Tis11B_N; Tis11B like protein, N terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    43222402..43226606 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    43227768..43231972 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47974.3 GenPept UniProtKB/Swiss-Prot:P47974

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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