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nlrc6 NLR family CARD domain containing 6 [ Danio rerio (zebrafish) ]

Gene ID: 678565, updated on 2-Nov-2024

Summary

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Official Symbol
nlrc6provided by ZNC
Official Full Name
NLR family CARD domain containing 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-060421-8264
See related
Ensembl:ENSDARG00000091320 AllianceGenome:ZFIN:ZDB-GENE-060421-8264
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
NACHT; nlrp12e; zgc:136791
Summary
Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See nlrc6 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (54766884..54785185)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54089219..54107532)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase type 2 alpha Neighboring gene arginine vasopressin induced 1 Neighboring gene NACHT, LRR and PYD domains-containing protein 12 Neighboring gene si:ch211-196h16.5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC136791

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 3; uncharacterized protein LOC678565
Names
LRR and PYD domains-containing protein 12e
Nacht 1.01

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    54766884..54785185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005160181.5 → XP_005160238.1  NACHT, LRR and PYD domains-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B7E5, A5PF24
    Related
    ENSDARP00000122806.1, ENSDART00000144759.3
    Conserved Domains (5) summary
    COG4886
    Location:660 → 908
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:629 → 930
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:694 → 722
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:128 → 295
    NACHT; NACHT domain
    pfam14484
    Location:47 → 117
    FISNA; Fish-specific NACHT associated domain

  2. XM_068221909.1 → XP_068078010.1  NACHT, LRR and PYD domains-containing protein 3 isoform X2

  3. XM_021477438.2 → XP_021333113.1  NACHT, LRR and PYD domains-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M9Q1B1
    Conserved Domains (4) summary
    sd00034
    Location:665 → 693
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:128 → 295
    NACHT; NACHT domain
    pfam14484
    Location:47 → 117
    FISNA; Fish-specific NACHT associated domain
    cl26161
    Location:629 → 794
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001040323.1: Suppressed sequence

    Description
    NM_001040323.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: zgc:174180 (GeneID:100008100).
Nucleotide Protein Strain
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