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mcph1 microcephalin 1 [ Danio rerio (zebrafish) ]

Gene ID: 678616, updated on 2-Nov-2024

Summary

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Official Symbol
mcph1provided by ZNC
Official Full Name
microcephalin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060421-6122
See related
Ensembl:ENSDARG00000058372 AllianceGenome:ZFIN:ZDB-GENE-060421-6122
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:136403
Summary
Human ortholog(s) of this gene implicated in breast cancer; endometrial cancer; microcephaly; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 1. Orthologous to human MCPH1 (microcephalin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mcph1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (6286594..6324011, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (6158134..6195551, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137487360 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon) Neighboring gene angiopoietin 2a Neighboring gene uncharacterized LOC101884841 Neighboring gene CUB and Sushi multiple domains 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Effects of microgravity simulation on zebrafish transcriptomes and bone physiology-exposure starting at 5 days post fertilization. Aceto J, et al. NPJ Microgravity, 2016. PMID 28725727, Free PMC Article
  2. Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity. Aceto J, et al. PLoS One, 2015. PMID 26061167, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC136403

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  

General protein information

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Preferred Names
microcephalin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040363.2 → NP_001035453.2  microcephalin isoform 2

    Status: VALIDATED

    Source sequence(s)
    CU929061, EH544828
    UniProtKB/TrEMBL
    A0A8M1N8U7, F8W5H6
    Related
    ENSDARP00000125093.1, ENSDART00000148907.3
    Conserved Domains (3) summary
    cd00027
    Location:294 → 347
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12738
    Location:16 → 82
    PTCB-BRCT; twin BRCT domain
    cl00038
    Location:390 → 461
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...

  2. NM_001430843.1 → NP_001417772.1  microcephalin isoform 1

    Status: VALIDATED

    Source sequence(s)
    CU929061
    UniProtKB/TrEMBL
    A0A8M2B3G0

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    6286594..6324011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068212935.1 → XP_068069036.1  microcephalin isoform X2

  2. XM_005157089.5 → XP_005157146.1  microcephalin isoform X1

    See identical proteins and their annotated locations for XP_005157146.1

    UniProtKB/TrEMBL
    A0A8M2B3G0
    Conserved Domains (3) summary
    cd00027
    Location:559 → 612
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam12738
    Location:16 → 82
    PTCB-BRCT; twin BRCT domain
    cl00038
    Location:655 → 726
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
Nucleotide Protein Strain
Heading Accession and Version

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