U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

flcn folliculin [ Danio rerio (zebrafish) ]

Gene ID: 678628, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
flcnprovided by ZNC
Official Full Name
folliculinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060421-3470
See related
Ensembl:ENSDARG00000062385 AllianceGenome:ZFIN:ZDB-GENE-060421-3470
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fe38g11; zgc:136982
Summary
Predicted to contribute to GTPase activator activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of TORC1 signaling; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in several cellular components, including cilium; lysosomal membrane; and microtubule cytoskeleton. Predicted to be active in cytosol. Is expressed in brain; hatching gland; pectoral fin bud; retina; and tail bud. Used to study Birt-Hogg-Dube syndrome. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See flcn in Genome Data Viewer
Location:
chromosome: 16
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (13818529..13846001)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (13928380..13955881)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene tweety family member 1 Neighboring gene leukocyte receptor cluster (LRC) member 9 Neighboring gene zgc:174888 Neighboring gene glutamate-rich WD repeat containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports. Toro JR, et al. J Med Genet, 2008 Jun. PMID 18234728, Free PMC Article
  2. Expression and knockdown of zebrafish folliculin suggests requirement for embryonic brain morphogenesis. Kenyon EJ, et al. BMC Dev Biol, 2016 Jul 8. PMID 27391801, Free PMC Article
  3. The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis. Ong AJS, et al. Proc Natl Acad Sci U S A, 2023 May 30. PMID 37216554, Free PMC Article
  4. AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR. Collodet C, et al. FASEB J, 2019 Nov. PMID 31404503, Free PMC Article
  5. A lysosomal regulatory circuit essential for the development and function of microglia. Iyer H, et al. Sci Adv, 2022 Sep 2. PMID 36044568, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC136982

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
contributes_to GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
folliculin
NP_001035463.1
XP_005157956.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040373.1 → NP_001035463.1  folliculin

    See identical proteins and their annotated locations for NP_001035463.1

    Status: PROVISIONAL

    Source sequence(s)
    BC115356
    UniProtKB/TrEMBL
    Q1RLN8
    Related
    ENSDARP00000084624.4, ENSDART00000090191.6
    Conserved Domains (2) summary
    pfam11704
    Location:93 → 253
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:329 → 543
    Folliculin_C; Folliculin C-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    13818529..13846001
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157899.4 → XP_005157956.1  folliculin isoform X1

    UniProtKB/TrEMBL
    A0A8M2B4W4, F1R3E5
    Related
    ENSDARP00000133243.1, ENSDART00000163251.3
    Conserved Domains (2) summary
    pfam11704
    Location:93 → 253
    Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    pfam16692
    Location:329 → 543
    Folliculin_C; Folliculin C-terminal domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394957.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    340243..367497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools