Wfdc1 WAP four-disulfide core domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wfdc1provided by MGI
Official Full Name: WAP four-disulfide core domain 1provided by MGI
Primary source: MGI:MGI:1915116
See related: Ensembl:ENSMUSG00000023336 AllianceGenome:MGI:1915116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ps20; 2310058A03Rik
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of inflammatory response and negative regulation of wound healing. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in eye; male reproductive gland or organ; midbrain; and parathyroid gland. Orthologous to human WFDC1 (WAP four-disulfide core domain 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Broad expression in bladder adult (RPKM 63.2), colon adult (RPKM 55.9) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 E1; 8 68.15 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (120393104..120414759)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (119666365..119688020)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WFDC1/ps20 modulates core host response mechanisms, in part, via regulation of osteopontin and MMP-9 activity. Release from WFDC1 regulation is likely a key component of inflammatory and repair response mechanisms.
Title: WFDC1 is a key modulator of inflammatory and wound repair responses.
These data suggest roles for ps20 in regulating expression of neutrophil-specific chemotactic factors, thereby potentially modulating neutrophil migration, and in modulating neutrophil susceptibility to murine hepatitis virus -1 infection.
Title: WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection.
ps20 may be a TGF-beta1-induced regulator of angiogenesis that functions by either promoting endothelial cell migration or by contributing to pericyte stabilization of newly formed vascular structures.
Title: Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: WAP four-disulfide core domain protein 1

Names: prostate stromal protein ps20; ps20 growth inhibitor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023395.2 → NP_075884.1 WAP four-disulfide core domain protein 1 precursor

See identical proteins and their annotated locations for NP_075884.1

Status: VALIDATED

Source sequence(s)

AK132541, AK161606

Consensus CDS

CCDS22711.1

UniProtKB/Swiss-Prot

Q8R110, Q9ESH5

UniProtKB/TrEMBL

B7ZNL1, Q3UQ76

Related

ENSMUSP00000024107.6, ENSMUST00000024107.7

Conserved Domains (1) summary

cl00156
Location:73 → 99

WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...