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Eloc elongin C [ Mus musculus (house mouse) ]

Gene ID: 67923, updated on 10-Oct-2024

Summary

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Official Symbol
Elocprovided by MGI
Official Full Name
elongin Cprovided by MGI
Primary source
MGI:MGI:1915173
See related
Ensembl:ENSMUSG00000079658 AllianceGenome:MGI:1915173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tceb1; 2610043E24Rik; 2610301I15Rik
Summary
Predicted to be involved in positive regulation of transcription elongation from RNA polymerase II promoter and ubiquitin-dependent protein catabolic process. Part of elongin complex. Is expressed in several structures, including alimentary system; ganglia; musculature; nose; and urinary system. Orthologous to human ELOC (elongin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 25.1), frontal lobe adult (RPKM 20.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Eloc in Genome Data Viewer
Location:
1 A3; 1 5.1 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (16711949..16727652, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (16641725..16657428, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene RIKEN cDNA C130013N14 gene Neighboring gene ubiquitin-conjugating enzyme E2W (putative) Neighboring gene STARR-positive B cell enhancer ABC_E4305 Neighboring gene RIKEN cDNA D030040B21 gene Neighboring gene STARR-positive B cell enhancer ABC_E5743 Neighboring gene isopentenyl-diphosphate delta isomerase, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TCEB1 promotes invasion of prostate cancer cells. Jalava SE, et al. Int J Cancer, 2009 Jan 1. PMID 18844214
  2. v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells. Limnander A, et al. Mol Cell, 2004 Aug 13. PMID 15304214
  3. Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response. Desimone MC, et al. J Natl Cancer Inst, 2013 Sep 18. PMID 23990666, Free PMC Article
  4. Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes. Kim YK, et al. Acta Crystallogr D Biol Crystallogr, 2013 Aug. PMID 23897481
  5. The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase. Babon JJ, et al. J Mol Biol, 2008 Sep 12. PMID 18590740, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EPOP (E130012A19Rik) interacts with elongin B, elongin C, and USP7 to modulate the chromatin landscape.
    Title: EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.
  2. EPOP (E130012A19Rik) functionally links elongin B, elongin C, and polycomb in pluripotent stem cells.
    Title: EPOP Functionally Links Elongin and Polycomb in Pluripotent Stem Cells.
  3. Crystal structure shows interaction between SOCS2-elongin BC and Cullin-5.
    Title: Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes.
  4. PRAME expression in leukaemic cell lines is upregulated by IFN gamma and LPS, suggesting a possible role in immune responses. PRAME associates with Elongin BC complexes by binding Elongin C.
    Title: PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.
  5. TCEB1 promotes invasion of prostate cancer cells and is involved in development of hormone-refractory prostate cancer
    Title: TCEB1 promotes invasion of prostate cancer cells.
  6. Elongin B/C recruitment regulates substrate binding by CIS
    Title: Elongin B/C recruitment regulates substrate binding by CIS.
  7. SOCS box acts as an independent binding domain capable of recruiting elonginBC and cullin5 to promote E3 ligase formation.
    Title: The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in target-directed miRNA degradation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul5-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of VCB complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of elongin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongin complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
elongin-C
Names
RNA polymerase II transcription factor SIII subunit C
SIII p15
elongin 15 kDa subunit
stromal membrane-associated protein SMAP1B homolog
transcription elongation factor B (SIII), polypeptide 1
transcription elongation factor B polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310470.2 → NP_001297399.1  elongin-C isoform 1

    See identical proteins and their annotated locations for NP_001297399.1

    Status: VALIDATED

    Source sequence(s)
    AC157362
    Consensus CDS
    CCDS78549.1
    UniProtKB/TrEMBL
    A0A087WNT1
    Related
    ENSMUSP00000139480.2, ENSMUST00000187910.7
    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  2. NM_001430012.1 → NP_001416941.1  elongin-C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/TrEMBL
    A0A087WNT1

  3. NM_001430013.1 → NP_001416942.1  elongin-C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/TrEMBL
    A0A087WNT1

  4. NM_001430014.1 → NP_001416943.1  elongin-C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/TrEMBL
    A0A087WNT1

  5. NM_001430015.1 → NP_001416944.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  6. NM_001430016.1 → NP_001416945.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  7. NM_001430017.1 → NP_001416946.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  8. NM_001430018.1 → NP_001416947.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  9. NM_001430019.1 → NP_001416948.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  10. NM_001430020.1 → NP_001416949.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  11. NM_001430021.1 → NP_001416950.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  12. NM_001430022.1 → NP_001416951.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  13. NM_001430023.1 → NP_001416952.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  14. NM_001430024.1 → NP_001416953.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  15. NM_001430025.1 → NP_001416954.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  16. NM_001430026.1 → NP_001416955.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  17. NM_001430028.1 → NP_001416957.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  18. NM_001430030.1 → NP_001416959.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  19. NM_001430032.1 → NP_001416961.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  20. NM_001430033.1 → NP_001416962.1  elongin-C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC157362
    UniProtKB/Swiss-Prot
    P83940, Q63182

  21. NM_026456.5 → NP_080732.1  elongin-C isoform 2

    See identical proteins and their annotated locations for NP_080732.1

    Status: VALIDATED

    Source sequence(s)
    AC157362
    Consensus CDS
    CCDS35517.1
    UniProtKB/Swiss-Prot
    P83940, Q63182
    UniProtKB/TrEMBL
    A0A087WQE6
    Related
    ENSMUSP00000140422.2, ENSMUST00000188641.7
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    16711949..16727652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495561.3 → XP_006495624.1  elongin-C isoform X2

    Related
    ENSMUSP00000111009.4, ENSMUST00000115352.10
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  2. XM_006495564.3 → XP_006495627.1  elongin-C isoform X2

    Related
    ENSMUSP00000140962.2, ENSMUST00000186948.7
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  3. XM_011238403.3 → XP_011236705.1  elongin-C isoform X1

    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  4. XM_006495559.4 → XP_006495622.1  elongin-C isoform X1

    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  5. XM_006495562.3 → XP_006495625.1  elongin-C isoform X2

    Related
    ENSMUSP00000139675.2, ENSMUST00000185771.7
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  6. XM_006495558.4 → XP_006495621.1  elongin-C isoform X1

    See identical proteins and their annotated locations for XP_006495621.1

    UniProtKB/TrEMBL
    A0A087WNT1
    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  7. XM_006495563.4 → XP_006495626.1  elongin-C isoform X2

    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  8. XM_030242571.2 → XP_030098431.1  elongin-C isoform X1

    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  9. XM_036153232.1 → XP_036009125.1  elongin-C isoform X1

    UniProtKB/TrEMBL
    A0A087WNT1
    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  10. XM_030242577.2 → XP_030098437.1  elongin-C isoform X2

    UniProtKB/Swiss-Prot
    P83940, Q63182
    UniProtKB/TrEMBL
    A0A087WQE6
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  11. XM_036153239.1 → XP_036009132.1  elongin-C isoform X2

    UniProtKB/Swiss-Prot
    P83940, Q63182
    UniProtKB/TrEMBL
    A0A087WQE6
    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  12. XM_030242579.1 → XP_030098439.1  elongin-C isoform X2

    Conserved Domains (1) summary
    cd18321
    Location:18 → 112
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins

  13. XM_017322272.2 → XP_017177761.1  elongin-C isoform X1

    UniProtKB/TrEMBL
    A0A087WNT1
    Conserved Domains (1) summary
    cd18321
    Location:40 → 134
    BTB_POZ_EloC; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83940.1 GenPept UniProtKB/Swiss-Prot:P83940

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